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Mouse Anti-TDO2 Recombinant Antibody (CBYJT-2446) (CBMAB-T1592-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TDO2 (Tryptophan 2, 3-Dioxygenase). The antibody can be used for immunoassay techniques, such as IHC, WB.
See all TDO2 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
CBYJT-2446
Antibody Isotype
IgG
Application
IHC, WB

Basic Information

Immunogen
Recombinant protein fragment corresponding to human TDO2, fused to GST-Tag
Specificity
Human, Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
100 mM Tris-glycine, 150 mM NaCl, pH 7.4
Preservative
0.05% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
tryptophan 2,3-dioxygenase
Introduction
TDO2 is a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine production may also function in cancer through the suppression of antitumor immune responses, and single nucleotide polymorphisms in this gene may be associated with autism.
Entrez Gene ID
Human6999
Mouse56720
UniProt ID
HumanP48775
MouseP48776
Alternative Names
Tryptophan 2, 3-Dioxygenase; Tryptamin 2, 3-Dioxygenase; Tryptophan Oxygenase; Tryptophan Pyrrolase; Tryptophanase; EC 1.13.11.11
Function
Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.
Biological Process
Biological Process protein homotetramerizationIDA:UniProtKB2 Publications
Biological Process response to nitroglycerinIEA:Ensembl
Biological Process tryptophan catabolic process to acetyl-CoAIBA:GO_Central1 Publication
Biological Process tryptophan catabolic process to kynurenineIDA:UniProtKB1 Publication
Cellular Location
Cytosol
Involvement in disease
Hypertryptophanemia (HYPTRP):
An autosomal recessive condition characterized by persistent hypertryptophanemia and hyperserotoninemia.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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