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Mouse Anti-TDO2 Recombinant Antibody (CBYJT-2443) (CBMAB-T1589-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TDO2 (Tryptophan 2, 3-Dioxygenase). The antibody can be used for immunoassay techniques, such as WB, IHC.
See all TDO2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-2443
Antibody Isotype
IgG1
Application
WB, IHC

Basic Information

Immunogen
Full length human recombinant protein of human TDO2(NP_005642) produced in HEK293T cell
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.3, 1% BSA, 50% Glycerol
Preservative
0.02% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
tryptophan 2,3-dioxygenase
Introduction
TDO2 is a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine production may also function in cancer through the suppression of antitumor immune responses, and single nucleotide polymorphisms in this gene may be associated with autism.
Entrez Gene ID
6999
UniProt ID
P48775
Alternative Names
Tryptophan 2, 3-Dioxygenase; Tryptamin 2, 3-Dioxygenase; Tryptophan Oxygenase; Tryptophan Pyrrolase; Tryptophanase; EC 1.13.11.11
Function
Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.
Biological Process
Biological Process protein homotetramerizationIDA:UniProtKB2 Publications
Biological Process response to nitroglycerinIEA:Ensembl
Biological Process tryptophan catabolic process to acetyl-CoAIBA:GO_Central1 Publication
Biological Process tryptophan catabolic process to kynurenineIDA:UniProtKB1 Publication
Cellular Location
Cytosol
Involvement in disease
Hypertryptophanemia (HYPTRP):
An autosomal recessive condition characterized by persistent hypertryptophanemia and hyperserotoninemia.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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