Rabbit Anti-TIAL1 Recombinant Antibody (C92B9) (CBMAB-CP2848-LY)

Name: Rabbit Anti-TIAL1 Recombinant Antibody (C92B9)
SKU: CBMAB-CP2848-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Rabbit

Clone

C92B9

Application

WB, IP, IHC-P, IF (ICC), FC

Immunogen

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Lys60 of human TRAIL, within the extracellular region of the protein.

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

100 µg/ml BSA, 50% glycerol

Preservative

0.02% sodium azide

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

TIAL1 Gene(Protein Coding) TIA1 Cytotoxic Granule Associated RNA Binding Protein Like 1

Introduction

The protein encoded by this gene is a member of a family of RNA-binding proteins, has three RNA recognition motifs (RRMs), and binds adenine and uridine-rich elements in mRNA and pre-mRNAs of a wide range of genes. It regulates various activities including translational control, splicing and apoptosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The different isoforms have been show to function differently with respect to post-transcriptional silencing. [provided by RefSeq, Jul 2008]

Entrez Gene ID

7073

UniProt ID

Q01085

Alternative Names

TIA1 Cytotoxic Granule Associated RNA Binding Protein Like 1; TIA1 Cytotoxic Granule-Associated RNA-Binding Protein-Like 1; Aging-Associated Gene 7 Protein; T-Cluster Binding Protein; TIA-1-Related Nucleolysin; TIA-1-Related Protein; Nucleolysin TIAR; TCBP; TIAR;

Function

RNA-binding protein involved in alternative pre-RNA splicing and in cytoplasmic stress granules formation (PubMed:1326761, PubMed:8576255, PubMed:17488725, PubMed:10613902).
Shows a preference for uridine-rich RNAs (PubMed:8576255).
Activates splicing of alternative exons with weak 5' splice sites followed by a U-rich stretch on its own pre-mRNA and on TIA1 mRNA (By similarity).
Promotes the inclusion of TIA1 exon 5 to give rise to the long isoform (isoform a) of TIA1 (PubMed:17488725).
Acts downstream of the stress-induced phosphorylation of EIF2S1/EIF2A to promote the recruitment of untranslated mRNAs to cytoplasmic stress granules (SG) (PubMed:10613902).
Possesses nucleolytic activity against cytotoxic lymphocyte target cells (PubMed:1326761).
May be involved in apoptosis (PubMed:1326761).

Biological Process

Biological Process apoptotic processSource:ProtInc1 Publication
Biological Process defense responseSource:ProtInc1 Publication
Biological Process germ cell developmentSource:Ensembl
Biological Process negative regulation of cell population proliferationSource:FlyBase1 Publication
Biological Process positive regulation of hippo signalingSource:FlyBase1 Publication
Biological Process positive regulation of miRNA-mediated gene silencingSource:FlyBase1 Publication
Biological Process positive regulation of stem cell proliferationSource:Ensembl
Biological Process regulation of transcription by RNA polymerase IISource:ProtInc1 Publication
Biological Process stem cell divisionSource:Ensembl
Biological Process stem cell proliferationSource:Ensembl

Cellular Location

Nucleus
Cytoplasm
Cytolytic granule
Cytoplasm, Stress granule
Nuclear import seems to be coupled to RNA polymerase II transcription and may be dependent on RNA-binding (By similarity).
Accumulates in cytoplasmic stress granules (SG) following cellular damage (PubMed:10613902).

PTM

Phosphorylated by MAPK14 following DNA damage, releasing TIAR from GADD45A mRNA.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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