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Rabbit Anti-TIAL1 Recombinant Antibody (D26E4) (CBMAB-CP2763-LY)

The product is antibody recognizes TIAL1. The antibody D26E4 immunoassay techniques such as: WB,IP,IF (ICC).
See all TIAL1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat, Monkey
Clone
D26E4
Antibody Isotype
IgG
Application
WB, IP, IF (ICC)

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human TIAR protein.
Specificity
Human, Mouse, Rat, Monkey
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
TIAL1 Gene(Protein Coding) TIA1 Cytotoxic Granule Associated RNA Binding Protein Like 1
Introduction
The protein encoded by this gene is a member of a family of RNA-binding proteins, has three RNA recognition motifs (RRMs), and binds adenine and uridine-rich elements in mRNA and pre-mRNAs of a wide range of genes. It regulates various activities including translational control, splicing and apoptosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The different isoforms have been show to function differently with respect to post-transcriptional silencing. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human7073
Mouse21843
Rat361655
Monkey703249
UniProt ID
HumanQ01085
MouseP70318
RatQ5BJN3
MonkeyH9EMX1
Alternative Names
TIA1 Cytotoxic Granule Associated RNA Binding Protein Like 1; TIA1 Cytotoxic Granule-Associated RNA-Binding Protein-Like 1; Aging-Associated Gene 7 Protein; T-Cluster Binding Protein; TIA-1-Related Nucleolysin; TIA-1-Related Protein; Nucleolysin TIAR; TCBP; TIAR;
Function
RNA-binding protein involved in alternative pre-RNA splicing and in cytoplasmic stress granules formation (PubMed:1326761, PubMed:8576255, PubMed:17488725, PubMed:10613902).
Shows a preference for uridine-rich RNAs (PubMed:8576255).
Activates splicing of alternative exons with weak 5' splice sites followed by a U-rich stretch on its own pre-mRNA and on TIA1 mRNA (By similarity).
Promotes the inclusion of TIA1 exon 5 to give rise to the long isoform (isoform a) of TIA1 (PubMed:17488725).
Acts downstream of the stress-induced phosphorylation of EIF2S1/EIF2A to promote the recruitment of untranslated mRNAs to cytoplasmic stress granules (SG) (PubMed:10613902).
Possesses nucleolytic activity against cytotoxic lymphocyte target cells (PubMed:1326761).
May be involved in apoptosis (PubMed:1326761).
Biological Process
Biological Process apoptotic processSource:ProtInc1 Publication
Biological Process defense responseSource:ProtInc1 Publication
Biological Process germ cell developmentSource:Ensembl
Biological Process negative regulation of cell population proliferationSource:FlyBase1 Publication
Biological Process positive regulation of hippo signalingSource:FlyBase1 Publication
Biological Process positive regulation of miRNA-mediated gene silencingSource:FlyBase1 Publication
Biological Process positive regulation of stem cell proliferationSource:Ensembl
Biological Process regulation of transcription by RNA polymerase IISource:ProtInc1 Publication
Biological Process stem cell divisionSource:Ensembl
Biological Process stem cell proliferationSource:Ensembl
Cellular Location
Nucleus
Cytoplasm
Cytolytic granule
Cytoplasm, Stress granule
Nuclear import seems to be coupled to RNA polymerase II transcription and may be dependent on RNA-binding (By similarity).
Accumulates in cytoplasmic stress granules (SG) following cellular damage (PubMed:10613902).
PTM
Phosphorylated by MAPK14 following DNA damage, releasing TIAR from GADD45A mRNA.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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