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Mouse Anti-TIAL1 Recombinant Antibody (CBYJT-3108) (CBMAB-T2376-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TIAL1 (TIA1 Cytotoxic Granule Associated RNA Binding Protein Like 1). The antibody can be used for immunoassay techniques, such as WB, IF, IHC, IP.
See all TIAL1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Dog, Frog, Rat
Clone
CBYJT-3108
Antibody Isotype
IgG1
Application
WB, IF, IHC, IP

Basic Information

Immunogen
Human TIAR aa. 161-365
Specificity
Human, Mouse, Dog, Frog, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 161-365

Target

Full Name
TIAL1 Gene(Protein Coding) TIA1 Cytotoxic Granule Associated RNA Binding Protein Like 1
Introduction
TIAL1 is a member of a family of RNA-binding proteins, has three RNA recognition motifs (RRMs), and binds adenine and uridine-rich elements in mRNA and pre-mRNAs of a wide range of genes. It regulates various activities including translational control, splicing and apoptosis.
Entrez Gene ID
Human7073
Mouse21843
Rat361655
Chicken112529920
Frog113225353
UniProt ID
HumanQ01085
MouseP70318
RatQ5BJN3
ChickenA0A1L1RXF5
FrogQ28BS8
Alternative Names
TIA1 Cytotoxic Granule Associated RNA Binding Protein Like 1; TIA1 Cytotoxic Granule-Associated RNA-Binding Protein-Like 1; Aging-Associated Gene 7 Protein; T-Cluster Binding Protein; TIA-1-Related Nucleolysin; TIA-1-Related Protein; Nucleolysin TIAR; TCBP; TIAR
Function
RNA-binding protein involved in alternative pre-RNA splicing and in cytoplasmic stress granules formation (PubMed:1326761, PubMed:8576255, PubMed:17488725, PubMed:10613902).
Shows a preference for uridine-rich RNAs (PubMed:8576255).
Activates splicing of alternative exons with weak 5' splice sites followed by a U-rich stretch on its own pre-mRNA and on TIA1 mRNA (By similarity).
Promotes the inclusion of TIA1 exon 5 to give rise to the long isoform (isoform a) of TIA1 (PubMed:17488725).
Acts downstream of the stress-induced phosphorylation of EIF2S1/EIF2A to promote the recruitment of untranslated mRNAs to cytoplasmic stress granules (SG) (PubMed:10613902).
Possesses nucleolytic activity against cytotoxic lymphocyte target cells (PubMed:1326761).
May be involved in apoptosis (PubMed:1326761).
Biological Process
Biological Process apoptotic processSource:ProtInc1 Publication
Biological Process defense responseSource:ProtInc1 Publication
Biological Process germ cell developmentSource:Ensembl
Biological Process negative regulation of cell population proliferationSource:FlyBase1 Publication
Biological Process positive regulation of hippo signalingSource:FlyBase1 Publication
Biological Process positive regulation of miRNA-mediated gene silencingSource:FlyBase1 Publication
Biological Process positive regulation of stem cell proliferationSource:Ensembl
Biological Process regulation of transcription by RNA polymerase IISource:ProtInc1 Publication
Biological Process stem cell divisionSource:Ensembl
Biological Process stem cell proliferationSource:Ensembl
Cellular Location
Nucleus
Cytoplasm
Cytolytic granule
Cytoplasm, Stress granule
Nuclear import seems to be coupled to RNA polymerase II transcription and may be dependent on RNA-binding (By similarity).
Accumulates in cytoplasmic stress granules (SG) following cellular damage (PubMed:10613902).
PTM
Phosphorylated by MAPK14 following DNA damage, releasing TIAR from GADD45A mRNA.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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