TIAL1

The protein encoded by this gene is a member of a family of RNA-binding proteins, has three RNA recognition motifs (RRMs), and binds adenine and uridine-rich elements in mRNA and pre-mRNAs of a wide range of genes. It regulates various activities including translational control, splicing and apoptosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The different isoforms have been show to function differently with respect to post-transcriptional silencing. [provided by RefSeq, Jul 2008]

Full Name

TIAL1 Gene(Protein Coding) TIA1 Cytotoxic Granule Associated RNA Binding Protein Like 1

Function

RNA-binding protein involved in alternative pre-RNA splicing and in cytoplasmic stress granules formation (PubMed:1326761, PubMed:8576255, PubMed:17488725, PubMed:10613902).
Shows a preference for uridine-rich RNAs (PubMed:8576255).
Activates splicing of alternative exons with weak 5' splice sites followed by a U-rich stretch on its own pre-mRNA and on TIA1 mRNA (By similarity).
Promotes the inclusion of TIA1 exon 5 to give rise to the long isoform (isoform a) of TIA1 (PubMed:17488725).
Acts downstream of the stress-induced phosphorylation of EIF2S1/EIF2A to promote the recruitment of untranslated mRNAs to cytoplasmic stress granules (SG) (PubMed:10613902).
Possesses nucleolytic activity against cytotoxic lymphocyte target cells (PubMed:1326761).
May be involved in apoptosis (PubMed:1326761).

Biological Process

Biological Process apoptotic processSource:ProtInc1 Publication
Biological Process defense responseSource:ProtInc1 Publication
Biological Process germ cell developmentSource:Ensembl
Biological Process negative regulation of cell population proliferationSource:FlyBase1 Publication
Biological Process positive regulation of hippo signalingSource:FlyBase1 Publication
Biological Process positive regulation of miRNA-mediated gene silencingSource:FlyBase1 Publication
Biological Process positive regulation of stem cell proliferationSource:Ensembl
Biological Process regulation of transcription by RNA polymerase IISource:ProtInc1 Publication
Biological Process stem cell divisionSource:Ensembl
Biological Process stem cell proliferationSource:Ensembl

Cellular Location

Nucleus
Cytoplasm
Cytolytic granule
Cytoplasm, Stress granule
Nuclear import seems to be coupled to RNA polymerase II transcription and may be dependent on RNA-binding (By similarity).
Accumulates in cytoplasmic stress granules (SG) following cellular damage (PubMed:10613902).

PTM

Phosphorylated by MAPK14 following DNA damage, releasing TIAR from GADD45A mRNA.