Mouse Anti-TLE4 Recombinant Antibody (CBLG1-2454) (CBMAB-G6626-LY)

Name: Mouse Anti-TLE4 Recombinant Antibody (CBLG1-2454)
SKU: CBMAB-G6626-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

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Basic Information

Host Animal

Mouse

Clone

CBLG1-2454

Application

Specificity

Human

Antibody Isotype

IgM

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Preservative

0.09% sodium azide

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Transducin-Like Enhancer Of Split 4

Introduction

TLE4 (Transducin Like Enhancer Of Split 4) is a Protein Coding gene.

Among its related pathways are Development NOTCH1-mediated pathway for NF-KB activity modulation and Signaling by NOTCH1.
Gene Ontology (GO) annotations related to this gene include chromatin binding and transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding.
An important paralog of this gene is TLE1.

Entrez Gene ID

7091

UniProt ID

Q04727

Alternative Names

Transducin Like Enhancer Of Split 4; Transducin-Like Enhancer Of Split 4 (E(Sp1) Homolog; Drosophila); Groucho-Related Protein 4; Grg-4; GRG4; Transducin-Like Enhancer Of Split 4; Homolog Of Drosophila E(Sp1); Transducin-Like Enhancer Protein 4; Enhancer Of Split Groucho 4;

Function

Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression (By similarity).

Biological Process

Biological Process cellular response to leukemia inhibitory factorSource:Ensembl
Biological Process negative regulation of canonical Wnt signaling pathwaySource:GO_Central1 Publication
Biological Process negative regulation of transcription by RNA polymerase IISource:Ensembl
Biological Process Wnt signaling pathwaySource:UniProtKB-KW

Cellular Location

Nucleus

PTM

Ubiquitinated by XIAP/BIRC4. This ubiquitination does not affect its stability, nuclear localization, or capacity to tetramerize but inhibits its interaction with TCF7L2/TCF4.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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