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Mouse Anti-Tle4 Recombinant Antibody (CBYJT-3300) (CBMAB-T2588-YJ)


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Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Human
Clone
CBYJT-3300
Antibody Isotype
IgG
Application
WB, IP, IF, IHC-P, ELISA

Basic Information

Immunogen
Amino acids 273-473 of TLE4 of mouse origin
Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 273-473

Target

Full Name
Transducin-Like Enhancer Of Split 4
Introduction
Tle4 functions in regulation of transcription, DNA-templated.
Entrez Gene ID
Human7091
Mouse21888
Rat25565
UniProt ID
HumanQ04727
MouseQ62441
RatQ07141
Alternative Names
Bce1; Grg4; Bce-1; grg-4; ESTM13; ESTM14; X83332; X83333; AA792082; 5730411M05Rik
Function
Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression (By similarity).
Biological Process
Biological Process cellular response to leukemia inhibitory factorSource:Ensembl
Biological Process negative regulation of canonical Wnt signaling pathwaySource:GO_Central1 Publication
Biological Process negative regulation of transcription by RNA polymerase IISource:Ensembl
Biological Process Wnt signaling pathwaySource:UniProtKB-KW
Cellular Location
Nucleus
PTM
Ubiquitinated by XIAP/BIRC4. This ubiquitination does not affect its stability, nuclear localization, or capacity to tetramerize but inhibits its interaction with TCF7L2/TCF4.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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