TLE4

Tle4 functions in regulation of transcription, DNA-templated.
Full Name
Transducin-Like Enhancer Of Split 4
Function
Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression (By similarity).
Biological Process
Biological Process cellular response to leukemia inhibitory factorSource:Ensembl
Biological Process negative regulation of canonical Wnt signaling pathwaySource:GO_Central1 Publication
Biological Process negative regulation of transcription by RNA polymerase IISource:Ensembl
Biological Process Wnt signaling pathwaySource:UniProtKB-KW
Cellular Location
Nucleus
PTM
Ubiquitinated by XIAP/BIRC4. This ubiquitination does not affect its stability, nuclear localization, or capacity to tetramerize but inhibits its interaction with TCF7L2/TCF4.
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Anti-TLE4 antibodies

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Mouse Anti-Tle4 Recombinant Antibody (CBYJT-3300) (CBMAB-T2588-YJ)

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Target: TLE4
Host: Mouse
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBYJT-3300
Application*: WB, IP, IF, P, E
Datasheet SDS

Mouse Anti-TLE4 Recombinant Antibody (CBYJT-3299) (CBMAB-T2587-YJ)

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Target: TLE4
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: CBYJT-3299
Application*: WB
Datasheet SDS

Mouse Anti-TLE4 Recombinant Antibody (CBLG1-2455) (CBMAB-G6627-LY)

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Target: TLE4
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: CBLG1-2455
Application*: WB
Datasheet SDS

Mouse Anti-TLE4 Recombinant Antibody (CBLG1-2454) (CBMAB-G6626-LY)

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Target: TLE4
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: CBLG1-2454
Application*: WB
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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