TLE4

Tle4 functions in regulation of transcription, DNA-templated.

Transducin-Like Enhancer Of Split 4

Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression (By similarity).

Biological Process cellular response to leukemia inhibitory factorSource:Ensembl
Biological Process negative regulation of canonical Wnt signaling pathwaySource:GO_Central1 Publication
Biological Process negative regulation of transcription by RNA polymerase IISource:Ensembl
Biological Process Wnt signaling pathwaySource:UniProtKB-KW

Nucleus

Ubiquitinated by XIAP/BIRC4. This ubiquitination does not affect its stability, nuclear localization, or capacity to tetramerize but inhibits its interaction with TCF7L2/TCF4.