Sign in or Register   Sign in or Register
  |  

Mouse Anti-TLE4 Recombinant Antibody (CBYJT-3299) (CBMAB-T2587-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TLE4 (Transducin Like Enhancer Of Split 4). The antibody can be used for immunoassay techniques, such as WB.
See all TLE4 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-3299
Antibody Isotype
IgM
Application
WB

Basic Information

Immunogen
This TLE4 Monoclonal antibody is generated from mouses immunized with a KLH conjugated synthetic peptide selected from the center region of human TLE4
Specificity
Human
Antibody Isotype
IgM
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS
Preservative
0.09% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Transducin-Like Enhancer Of Split 4
Introduction
TLE4 (Transducin Like Enhancer Of Split 4) is a Protein Coding gene. Among its related pathways are Development NOTCH1-mediated pathway for NF-KB activity modulation and Signaling by NOTCH1. Gene Ontology (GO) annotations related to TLE4 include chromatin binding and transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding. An important paralog of TLE4 is TLE1.
Entrez Gene ID
7091
UniProt ID
Q04727
Alternative Names
Transducin Like Enhancer Of Split 4; Transducin-Like Enhancer Of Split 4 (E(Sp1) Homolog, Drosophila); Groucho-Related Protein 4; Grg-4; GRG4; Transducin-Like Enhancer Of Split 4, Homolog Of Drosophila E(Sp1); Transducin-Like Enhancer Protein 4; Enhancer Of Split Groucho 4
Function
Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression (By similarity).
Biological Process
Biological Process cellular response to leukemia inhibitory factorSource:Ensembl
Biological Process negative regulation of canonical Wnt signaling pathwaySource:GO_Central1 Publication
Biological Process negative regulation of transcription by RNA polymerase IISource:Ensembl
Biological Process Wnt signaling pathwaySource:UniProtKB-KW
Cellular Location
Nucleus
PTM
Ubiquitinated by XIAP/BIRC4. This ubiquitination does not affect its stability, nuclear localization, or capacity to tetramerize but inhibits its interaction with TCF7L2/TCF4.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-TLE4 Recombinant Antibody (CBYJT-3299)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare