Mouse Anti-TLR5 Recombinant Antibody (85B152.5) (CBMAB-T2709-YJ)

Name: Mouse Anti-TLR5 Recombinant Antibody (85B152.5)
SKU: CBMAB-T2709-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

85B152.5

Application

WB, FC, IHC-P

Immunogen

This antibody was developed against KLH-conjugated synthetic peptide corresponding to a portion of human TLR5. It will cross-react with mouse TLR5 (NP_003259)

Specificity

Human, Mouse, Dog

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

toll-like receptor 5

Introduction

TLR5 encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. TLR5 recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of it mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.

Entrez Gene ID

Human	7100
Mouse	53791
Dog	488605

UniProt ID

Human	O60602
Mouse	Q9JLF7
Dog	A0A8I3NY74

Alternative Names

Toll Like Receptor 5; Toll/Interleukin-1 Receptor-Like Protein 3; Systemic Lupus Erythematosus Susceptibility 1; Toll-Like Receptor 5; TIL3; MELIOS; SLEB1; SLE1

Function

Pattern recognition receptor (PRR) located on the cell surface that participates in the activation of innate immunity and inflammatory response (PubMed:11323673, PubMed:18490781).
Recognizes small molecular motifs named pathogen-associated molecular pattern (PAMPs) expressed by pathogens and microbe-associated molecular patterns (MAMPs) usually expressed by resident microbiota (PubMed:29934223).
Upon ligand binding such as bacterial flagellins, recruits intracellular adapter proteins MYD88 and TRIF leading to NF-kappa-B activation, cytokine secretion and induction of the inflammatory response (PubMed:20855887, PubMed:11489966).
Plays thereby an important role in the relationship between the intestinal epithelium and enteric microbes and contributes to the gut microbiota composition throughout life (By similarity).

Biological Process

Biological Process cellular response to mechanical stimulusSource:UniProtKB1 Publication
Biological Process defense response to bacteriumSource:InterPro
Biological Process inflammatory responseSource:GO_Central1 Publication
Biological Process innate immune responseSource:UniProtKB-KW
Biological Process MyD88-dependent toll-like receptor signaling pathwaySource:InterPro
Biological Process positive regulation of interleukin-8 productionSource:BHF-UCL1 Publication
Biological Process positive regulation of toll-like receptor signaling pathwaySource:BHF-UCL1 Publication
Biological Process toll-like receptor 5 signaling pathwaySource:InterPro
Biological Process toll-like receptor signaling pathwaySource:GO_Central1 Publication

Cellular Location

Cell membrane

Topology

Extracellular: 21-639
Helical: 640-660
Cytoplasmic: 661-858

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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