This antibody was developed against KLH-conjugated synthetic peptide corresponding to a portion of human TLR5. It will cross-react with mouse TLR5 (NP_003259)
Human, Mouse, Dog
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
TLR5 encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. TLR5 recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of it mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.
Toll Like Receptor 5; Toll/Interleukin-1 Receptor-Like Protein 3; Systemic Lupus Erythematosus Susceptibility 1; Toll-Like Receptor 5; TIL3; MELIOS; SLEB1; SLE1