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Mouse Anti-TLR5 Recombinant Antibody (85B152.5) (CBMAB-T2709-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TLR5 (Toll Like Receptor 5). The antibody can be used for immunoassay techniques, such as WB, FC, IHC-P.
See all TLR5 antibodies
Published Data

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Dog
Clone
85B152.5
Antibody Isotype
IgG2a
Application
WB, FC, IHC-P

Basic Information

Immunogen
This antibody was developed against KLH-conjugated synthetic peptide corresponding to a portion of human TLR5. It will cross-react with mouse TLR5 (NP_003259)
Specificity
Human, Mouse, Dog
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
toll-like receptor 5
Introduction
TLR5 encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. TLR5 recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of it mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.
Entrez Gene ID
Human7100
Mouse53791
Dog488605
UniProt ID
Alternative Names
Toll Like Receptor 5; Toll/Interleukin-1 Receptor-Like Protein 3; Systemic Lupus Erythematosus Susceptibility 1; Toll-Like Receptor 5; TIL3; MELIOS; SLEB1; SLE1
Function
Pattern recognition receptor (PRR) located on the cell surface that participates in the activation of innate immunity and inflammatory response (PubMed:11323673, PubMed:18490781).
Recognizes small molecular motifs named pathogen-associated molecular pattern (PAMPs) expressed by pathogens and microbe-associated molecular patterns (MAMPs) usually expressed by resident microbiota (PubMed:29934223).
Upon ligand binding such as bacterial flagellins, recruits intracellular adapter proteins MYD88 and TRIF leading to NF-kappa-B activation, cytokine secretion and induction of the inflammatory response (PubMed:20855887, PubMed:11489966).
Plays thereby an important role in the relationship between the intestinal epithelium and enteric microbes and contributes to the gut microbiota composition throughout life (By similarity).
Biological Process
Biological Process cellular response to mechanical stimulusSource:UniProtKB1 Publication
Biological Process defense response to bacteriumSource:InterPro
Biological Process inflammatory responseSource:GO_Central1 Publication
Biological Process innate immune responseSource:UniProtKB-KW
Biological Process MyD88-dependent toll-like receptor signaling pathwaySource:InterPro
Biological Process positive regulation of interleukin-8 productionSource:BHF-UCL1 Publication
Biological Process positive regulation of toll-like receptor signaling pathwaySource:BHF-UCL1 Publication
Biological Process toll-like receptor 5 signaling pathwaySource:InterPro
Biological Process toll-like receptor signaling pathwaySource:GO_Central1 Publication
Cellular Location
Cell membrane
Topology
Extracellular: 21-639
Helical: 640-660
Cytoplasmic: 661-858
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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