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TLR5

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene product is expressed in myelomonocytic cells, and recognizes bacterial flagellin, a principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB and stimulates tumour necrosis factor-alpha production. [provided by RefSeq]
Full Name
toll-like receptor 5
Function
Pattern recognition receptor (PRR) located on the cell surface that participates in the activation of innate immunity and inflammatory response (PubMed:11323673, PubMed:18490781).
Recognizes small molecular motifs named pathogen-associated molecular pattern (PAMPs) expressed by pathogens and microbe-associated molecular patterns (MAMPs) usually expressed by resident microbiota (PubMed:29934223).
Upon ligand binding such as bacterial flagellins, recruits intracellular adapter proteins MYD88 and TRIF leading to NF-kappa-B activation, cytokine secretion and induction of the inflammatory response (PubMed:20855887, PubMed:11489966).
Plays thereby an important role in the relationship between the intestinal epithelium and enteric microbes and contributes to the gut microbiota composition throughout life (By similarity).
Biological Process
Biological Process cellular response to mechanical stimulusSource:UniProtKB1 Publication
Biological Process defense response to bacteriumSource:InterPro
Biological Process inflammatory responseSource:GO_Central1 Publication
Biological Process innate immune responseSource:UniProtKB-KW
Biological Process MyD88-dependent toll-like receptor signaling pathwaySource:InterPro
Biological Process positive regulation of interleukin-8 productionSource:BHF-UCL1 Publication
Biological Process positive regulation of toll-like receptor signaling pathwaySource:BHF-UCL1 Publication
Biological Process toll-like receptor 5 signaling pathwaySource:InterPro
Biological Process toll-like receptor signaling pathwaySource:GO_Central1 Publication
Cellular Location
Cell membrane
Topology
Extracellular: 21-639
Helical: 640-660
Cytoplasmic: 661-858

Anti-TLR5 antibodies

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Target: TLR5
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-C1994
Application*: F
Target: TLR5
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 1E1
Application*: WB, E
Target: TLR5
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 3E4
Application*: WB, E
Target: TLR5
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 1A11
Application*: SE, E
Target: TLR5
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 3A2
Application*: WB, E
Target: TLR5
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 3H6
Application*: WB, E
Target: TLR5
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4B2
Application*: WB, E
Target: TLR5
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 4D12
Application*: SE, E
Target: TLR5
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4F7
Application*: WB, E
Target: TLR5
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4G5
Application*: E, E
Target: TLR5
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-3392
Application*: E
Target: TLR5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3393
Application*: F, IH
Target: TLR5
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-3394
Application*: E, IC, IH, WB
Target: TLR5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3395
Application*: F, IH, MC
Target: TLR5
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Dog, Mouse
Clone: CBYJT-3396
Application*: F, IH, WB
Target: TLR5
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Dog
Clone: 19D759.2
Application*: WB, F, P, C
Target: TLR5
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Dog
Clone: 85B152.5
Application*: WB, F, P
Target: TLR5
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Mouse
Clone: CBWJC-4503
Application*: F, IP
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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