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Mouse Anti-TNFSF12 Recombinant Antibody (CBYJT-3924) (CBMAB-T3330-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TNFSF12 (TNF Superfamily Member 12). The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all TNFSF12 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
CBYJT-3924
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa49-134 from TNFSF12 (AAH19047) with GST tag. MW of the GST tag alone is 26kD
Specificity
Human, Mouse
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 49-134

Target

Full Name
TNFSF12 Gene(Protein Coding) TNF Superfamily Member 12
Introduction
TNFSF12 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. It is a ligand for the FN14/TWEAKR receptor. TNFSF12 has overlapping signaling functions with TNF, but displays a much wider tissue distribution. TNFSF12, which exists in both membrane-bound and secreted forms, can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. It is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis.
Entrez Gene ID
Human8742
Mouse21944
UniProt ID
HumanO43508
MouseO54907
Alternative Names
TNF Superfamily Member 12; Tumor Necrosis Factor (Ligand) Superfamily, Member 12; APO3 Ligand; APO3L; DR3LG; TWEAK; Tumor Necrosis Factor Ligand Superfamily Member 12
Function
Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion.
Biological Process
Biological Process angiogenesis Source:UniProtKB-KW
Biological Process apoptotic process Source:ProtInc1 Publication
Biological Process apoptotic signaling pathway Source:UniProtKB
Biological Process cell differentiation Source:UniProtKB-KW
Biological Process endothelial cell migration Source:UniProtKB1 Publication
Biological Process extrinsic apoptotic signaling pathway Source:GO_Central1 Publication
Biological Process immune response Source:InterPro
Biological Process positive regulation of angiogenesis Source:UniProtKB1 Publication
Biological Process positive regulation of endothelial cell proliferation Source:UniProtKB1 Publication
Biological Process positive regulation of extrinsic apoptotic signaling pathway Source:UniProtKB1 Publication
Biological Process positive regulation of protein catabolic process Source:MGI1 Publication
Biological Process signal transduction Source:ProtInc1 Publication
Cellular Location
Cell membrane
Tumor necrosis factor ligand superfamily member 12, secreted form
Secreted
Isoform TWE-PRIL
Cell membrane
Topology
Cytoplasmic: 1-21
Helical: 22-42
Extracellular: 43-249
PTM
The soluble form derives from the membrane form by proteolytic processing.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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