TNFSF12

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative splicing results in multiple transcript variants. Some transcripts skip the last exon of this gene and continue into the second exon of the neighboring TNFSF13 gene; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq, Oct 2010]

TNFSF12 Gene(Protein Coding) TNF Superfamily Member 12

Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion.

Biological Process angiogenesis Source:UniProtKB-KW
Biological Process apoptotic process Source:ProtInc1 Publication
Biological Process apoptotic signaling pathway Source:UniProtKB
Biological Process cell differentiation Source:UniProtKB-KW
Biological Process endothelial cell migration Source:UniProtKB1 Publication
Biological Process extrinsic apoptotic signaling pathway Source:GO_Central1 Publication
Biological Process immune response Source:InterPro
Biological Process positive regulation of angiogenesis Source:UniProtKB1 Publication
Biological Process positive regulation of endothelial cell proliferation Source:UniProtKB1 Publication
Biological Process positive regulation of extrinsic apoptotic signaling pathway Source:UniProtKB1 Publication
Biological Process positive regulation of protein catabolic process Source:MGI1 Publication
Biological Process signal transduction Source:ProtInc1 Publication

Cell membrane
Tumor necrosis factor ligand superfamily member 12, secreted form
Secreted
Isoform TWE-PRIL
Cell membrane

Cytoplasmic: 1-21
Helical: 22-42
Extracellular: 43-249

The soluble form derives from the membrane form by proteolytic processing.