TNFSF12
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative splicing results in multiple transcript variants. Some transcripts skip the last exon of this gene and continue into the second exon of the neighboring TNFSF13 gene; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq, Oct 2010]
Full Name
TNFSF12 Gene(Protein Coding) TNF Superfamily Member 12
Function
Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion.
Biological Process
Biological Process angiogenesis Source:UniProtKB-KW
Biological Process apoptotic process Source:ProtInc1 Publication
Biological Process apoptotic signaling pathway Source:UniProtKB
Biological Process cell differentiation Source:UniProtKB-KW
Biological Process endothelial cell migration Source:UniProtKB1 Publication
Biological Process extrinsic apoptotic signaling pathway Source:GO_Central1 Publication
Biological Process immune response Source:InterPro
Biological Process positive regulation of angiogenesis Source:UniProtKB1 Publication
Biological Process positive regulation of endothelial cell proliferation Source:UniProtKB1 Publication
Biological Process positive regulation of extrinsic apoptotic signaling pathway Source:UniProtKB1 Publication
Biological Process positive regulation of protein catabolic process Source:MGI1 Publication
Biological Process signal transduction Source:ProtInc1 Publication
Biological Process apoptotic process Source:ProtInc1 Publication
Biological Process apoptotic signaling pathway Source:UniProtKB
Biological Process cell differentiation Source:UniProtKB-KW
Biological Process endothelial cell migration Source:UniProtKB1 Publication
Biological Process extrinsic apoptotic signaling pathway Source:GO_Central1 Publication
Biological Process immune response Source:InterPro
Biological Process positive regulation of angiogenesis Source:UniProtKB1 Publication
Biological Process positive regulation of endothelial cell proliferation Source:UniProtKB1 Publication
Biological Process positive regulation of extrinsic apoptotic signaling pathway Source:UniProtKB1 Publication
Biological Process positive regulation of protein catabolic process Source:MGI1 Publication
Biological Process signal transduction Source:ProtInc1 Publication
Cellular Location
Cell membrane
Tumor necrosis factor ligand superfamily member 12, secreted form
Secreted
Isoform TWE-PRIL
Cell membrane
Tumor necrosis factor ligand superfamily member 12, secreted form
Secreted
Isoform TWE-PRIL
Cell membrane
Topology
Cytoplasmic: 1-21
Helical: 22-42
Extracellular: 43-249
Helical: 22-42
Extracellular: 43-249
PTM
The soluble form derives from the membrane form by proteolytic processing.
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Anti-TNFSF12 antibodies
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CompareTarget: TNFSF12
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse
Clone: 4H3
Application*: WB, E
Target: TNFSF12
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: CARL-1
Application*: F, IH, FN
Target: Tnfsf12
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: MTW-1
Application*: F
Target: Tnfsf12
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBYJT-3926
Application*: EC
Target: TNFSF12
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse
Clone: CBYJT-3924
Application*: E, WB
Target: TNFSF12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3923
Application*: WB
Target: TNFSF12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3922
Application*: E, F, IP
Target: TNFSF12
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: CBYJT-3921
Application*: WB, F, E, IC, IF
Target: TNFSF12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3920
Application*: EC
Target: Tnfsf12
Sensitivity: 0.0033 ng/mL
Detection Range: 0.006-0.8 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Mouse
Assay Type: Sandwich
Reactivity: Mouse
Target: TNFSF12
Sensitivity: 5.5 mg/mL
Detection Range: 10-4000 mg/mL
Sample Type: Serum, Plasma, Urine, Ascites, Cerebrospinal fluid, Tissue
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: TNFSF12
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 105-249
Tag: hFc Tag
Target: TNFSF12
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 105-249
Tag: rFc Tag
Target: TNFSF12
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 105-249
Tag: hFc Tag
Target: TNFSF12
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 94-249
Tag: Fc Tag
Target: TNFSF12
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CB370
Application*: IF, FC
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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