TNFSF12

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative splicing results in multiple transcript variants. Some transcripts skip the last exon of this gene and continue into the second exon of the neighboring TNFSF13 gene; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq, Oct 2010]
Full Name
TNFSF12 Gene(Protein Coding) TNF Superfamily Member 12
Function
Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion.
Biological Process
Biological Process angiogenesis Source:UniProtKB-KW
Biological Process apoptotic process Source:ProtInc1 Publication
Biological Process apoptotic signaling pathway Source:UniProtKB
Biological Process cell differentiation Source:UniProtKB-KW
Biological Process endothelial cell migration Source:UniProtKB1 Publication
Biological Process extrinsic apoptotic signaling pathway Source:GO_Central1 Publication
Biological Process immune response Source:InterPro
Biological Process positive regulation of angiogenesis Source:UniProtKB1 Publication
Biological Process positive regulation of endothelial cell proliferation Source:UniProtKB1 Publication
Biological Process positive regulation of extrinsic apoptotic signaling pathway Source:UniProtKB1 Publication
Biological Process positive regulation of protein catabolic process Source:MGI1 Publication
Biological Process signal transduction Source:ProtInc1 Publication
Cellular Location
Cell membrane
Tumor necrosis factor ligand superfamily member 12, secreted form
Secreted
Isoform TWE-PRIL
Cell membrane
Topology
Cytoplasmic: 1-21
Helical: 22-42
Extracellular: 43-249
PTM
The soluble form derives from the membrane form by proteolytic processing.
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Anti-TNFSF12 antibodies

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Mouse Anti-TNFSF12 Recombinant Antibody (4H3) (CBMAB-A9355-LY)

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Target: TNFSF12
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse
Clone: 4H3
Application*: WB, E
Datasheet SDS

Mouse Anti-TNFSF12 Recombinant Antibody (CARL-1) (CBMAB-C2139-CQ)

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Target: TNFSF12
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: CARL-1
Application*: F, IH, FN
Datasheet SDS

Rat Anti-Tnfsf12 Recombinant Antibody (MTW-1) (CBMAB-T3333-YJ)

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Target: Tnfsf12
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: MTW-1
Application*: F
Datasheet SDS

Rat Anti-Tnfsf12 Recombinant Antibody (CBYJT-3926) (CBMAB-T3332-YJ)

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Target: Tnfsf12
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBYJT-3926
Application*: EC
Datasheet SDS

Mouse Anti-TNFSF12 Recombinant Antibody (CBYJT-3924) (CBMAB-T3330-YJ)

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Target: TNFSF12
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse
Clone: CBYJT-3924
Application*: E, WB
Datasheet SDS

Mouse Anti-TNFSF12 Recombinant Antibody (CBYJT-3923) (CBMAB-T3329-YJ)

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Target: TNFSF12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3923
Application*: WB
Datasheet SDS

Mouse Anti-TNFSF12 Recombinant Antibody (CBYJT-3922) (CBMAB-T3327-YJ)

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Target: TNFSF12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3922
Application*: E, F, IP
Datasheet SDS

Mouse Anti-TNFSF12 Recombinant Antibody (CBYJT-3921) (CBMAB-T3326-YJ)

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Target: TNFSF12
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: CBYJT-3921
Application*: WB, F, E, IC, IF
Datasheet SDS

Mouse Anti-TNFSF12 Recombinant Antibody (CBYJT-3920) (CBMAB-T3325-YJ)

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Target: TNFSF12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3920
Application*: EC
Datasheet SDS

Mouse Anti-TNFSF12 Recombinant Antibody (CB370) (CBMAB-CS370LY)

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Target: TNFSF12
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CB370
Application*: IF, FC
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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