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Mouse Anti-TNNT3 Recombinant Antibody (CBYJT-4112) (CBMAB-T3551-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TNNT3 (Troponin T3, Fast Skeletal Type). The antibody can be used for immunoassay techniques, such as WB, ELISA.
See all TNNT3 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Rat
Clone
CBYJT-4112
Antibody Isotype
IgM, κ
Application
WB, ELISA

Basic Information

Immunogen
TNNT3 (NP_006748, 161 a.a. ~ 258 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa
Specificity
Human, Rat
Antibody Isotype
IgM, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
Ascites
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 161-258

Target

Full Name
TNNT3
Introduction
The binding of Ca(2+) to the trimeric troponin complex initiates the process of muscle contraction. Increased Ca(2+) concentrations produce a conformational change in the troponin complex that is transmitted to tropomyosin dimers situated along actin filaments. The altered conformation permits increased interaction between a myosin head and an actin filament which, ultimately, produces a muscle contraction. The troponin complex has protein subunits C, I, and T. Subunit C binds Ca(2+) and subunit I binds to actin and inhibits actin-myosin interaction. Subunit T binds the troponin complex to the tropomyosin complex and is also required for Ca(2+)-mediated activation of actomyosin ATPase activity. There are 3 different troponin T genes that encode tissue-specific isoforms of subunit T for fast skeletal-, slow skeletal-, and cardiac-muscle. TNNT3 encodes fast skeletal troponin T protein; also known as troponin T type 3.
Entrez Gene ID
Human7139
Rat24837
UniProt ID
HumanP45379
RatP50753
Alternative Names
Troponin T3, Fast Skeletal Type; Troponin T Type 3 (Skeletal, Fast); Beta-TnTF; TNTF; FTnT; Troponin T, Fast Skeletal Muscle; Fast Skeletal Muscle Troponin T; Troponin-T3, Skeletal, Fast; Troponin T3, Skeletal, Fast
Function
Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
Biological Process
Biological Process muscle contraction Source:GO_Central1 Publication
Biological Process positive regulation of calcium-dependent ATPase activity Source:UniProtKB2 Publications
Biological Process regulation of ATP-dependent activity Source:UniProtKB1 Publication
Biological Process regulation of striated muscle contraction Source:UniProtKB1 Publication
Biological Process sarcomere organization Source:GO_Central1 Publication
Biological Process skeletal muscle contraction Source:UniProtKB1 Publication
Cellular Location
cytosol
troponin complex
Involvement in disease
rthrogryposis, distal, 2B2 (DA2B2):
A form of distal arthrogryposis, a disease characterized by congenital joint contractures that mainly involve two or more distal parts of the limbs, in the absence of a primary neurological or muscle disease. Distal arthrogryposis type 2 is characterized by contractures of the hands and feet, and a distinctive face characterized by prominent nasolabial folds, small mouth and downslanting palpebral fissures. DA2B2 inheritance is autosomal dominant.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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