TNNT3

The binding of Ca(2+) to the trimeric troponin complex initiates the process of muscle contraction. Increased Ca(2+) concentrations produce a conformational change in the troponin complex that is transmitted to tropomyosin dimers situated along actin filaments. The altered conformation permits increased interaction between a myosin head and an actin filament which, ultimately, produces a muscle contraction. The troponin complex has protein subunits C, I, and T. Subunit C binds Ca(2+) and subunit I binds to actin and inhibits actin-myosin interaction. Subunit T binds the troponin complex to the tropomyosin complex and is also required for Ca(2+)-mediated activation of actomyosin ATPase activity.
Full Name
TNNT3
Function
Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
Biological Process
Biological Process muscle contraction Source:GO_Central1 Publication
Biological Process positive regulation of calcium-dependent ATPase activity Source:UniProtKB2 Publications
Biological Process regulation of ATP-dependent activity Source:UniProtKB1 Publication
Biological Process regulation of striated muscle contraction Source:UniProtKB1 Publication
Biological Process sarcomere organization Source:GO_Central1 Publication
Biological Process skeletal muscle contraction Source:UniProtKB1 Publication
Cellular Location
cytosol
troponin complex
Involvement in disease
rthrogryposis, distal, 2B2 (DA2B2):
A form of distal arthrogryposis, a disease characterized by congenital joint contractures that mainly involve two or more distal parts of the limbs, in the absence of a primary neurological or muscle disease. Distal arthrogryposis type 2 is characterized by contractures of the hands and feet, and a distinctive face characterized by prominent nasolabial folds, small mouth and downslanting palpebral fissures. DA2B2 inheritance is autosomal dominant.
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Anti-TNNT3 antibodies

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Mouse Anti-TNNT3 Recombinant Antibody (1F12) (CBMAB-A9402-LY)

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Target: TNNT3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1F12
Application*: WB, E
Datasheet SDS

Mouse Anti-TNNT3 Recombinant Antibody (CBYJT-4112) (CBMAB-T3551-YJ)

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Target: TNNT3
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human, Rat
Clone: CBYJT-4112
Application*: WB, E
Datasheet SDS

Mouse Anti-TNNT3 Recombinant Antibody (CBYJT-4111) (CBMAB-T3550-YJ)

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Target: TNNT3
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human
Clone: CBYJT-4111
Application*: E, WB
Datasheet SDS

Mouse Anti-TNNT3 Recombinant Antibody (CBYJT-4110) (CBMAB-T3549-YJ)

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Target: TNNT3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-4110
Application*: E, WB, P
Datasheet SDS

Mouse Anti-TNNT3 Recombinant Antibody (CBYJT-4109) (CBMAB-T3548-YJ)

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Target: TNNT3
Host: Mouse
Antibody Isotype: IgG
Specificity: Chicken, Mouse, Rat, Human
Clone: CBYJT-4109
Application*: WB, E
Datasheet SDS

Mouse Anti-TNNT3 Recombinant Antibody (T1/61) (CBMAB-T3547-YJ)

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Target: TNNT3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Chicken, Human, Quail
Clone: T1/61
Application*: E, IC, IF, C, P, WB
Datasheet SDS

Mouse Anti-TNNT3 Recombinant Antibody (CBYC-A1076) (CBMAB-A4892-YC)

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Target: TNNT3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYC-A1076
Application*: WB, IC, P, C, E
Datasheet SDS

Mouse Anti-TNNT3 Antibody (JLT12) (CBMAB-1654CQ)

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Target: TNNT3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rabbit, Axolotl, Cattle, Chicken, Human, Rat
Clone: JLT12
Application*: IF, IP, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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