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Mouse Anti-TNNT3 Antibody (JLT12) (CBMAB-1654CQ)

This product is a mouse antibody that recognizes TNNT3. The antibody JLT12 can be used for immunoassay techniques such as: IF, IP, WB.
See all TNNT3 antibodies

Summary

Host Animal
Mouse
Specificity
Rabbit, Axolotl, Cattle, Chicken, Human, Rat
Clone
JLT12
Antibody Isotype
IgG1
Application
IF, IP, WB

Basic Information

Immunogen
Skeletal muscle troponin T (TnT) (Full length protein)
Specificity
Rabbit, Axolotl, Cattle, Chicken, Human, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 71-151 of TnT2f

Target

Full Name
TNNT3
Introduction
This gene encodes fast skeletal troponin T protein; also known as troponin T type 3. Alternative splicing results in multiple transcript variants encoding additional distinct troponin T type 3 isoforms. Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Diseases associated with TNNT3 include Arthrogryposis, Distal, Type 2B and Arthrogryposis, Distal, Type 5. Among its related pathways are Striated Muscle Contraction and Cardiac conduction.
Entrez Gene ID
Human7140
Rabbit100009527
Rat24838
Chicken395761
Cattle282096
UniProt ID
HumanP45378
RabbitP02641
RatP09739
ChickenP12620
CattleQ8MKI3
Alternative Names
TnTf; fTnT
Function
Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
Biological Process
Biological Process muscle contraction Source:GO_Central1 Publication
Biological Process positive regulation of calcium-dependent ATPase activity Source:UniProtKB2 Publications
Biological Process regulation of ATP-dependent activity Source:UniProtKB1 Publication
Biological Process regulation of striated muscle contraction Source:UniProtKB1 Publication
Biological Process sarcomere organization Source:GO_Central1 Publication
Biological Process skeletal muscle contraction Source:UniProtKB1 Publication
Cellular Location
cytosol
troponin complex
Involvement in disease
rthrogryposis, distal, 2B2 (DA2B2):
A form of distal arthrogryposis, a disease characterized by congenital joint contractures that mainly involve two or more distal parts of the limbs, in the absence of a primary neurological or muscle disease. Distal arthrogryposis type 2 is characterized by contractures of the hands and feet, and a distinctive face characterized by prominent nasolabial folds, small mouth and downslanting palpebral fissures. DA2B2 inheritance is autosomal dominant.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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