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Rabbit Anti-TREML1 Recombinant Antibody (CBYJT-4618) (CBMAB-T4147-YJ)

Provided herein is a Rabbit monoclonal antibody, which binds to TREML1 (Triggering Receptor Expressed On Myeloid Cells Like 1). The antibody can be used for immunoassay techniques, such as ELISA.
See all TREML1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBYJT-4618
Antibody Isotype
IgG
Application
ELISA

Basic Information

Immunogen
Recombinant Human TREML1 protein
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Triggering Receptor Expressed On Myeloid Cells-Like 1
Introduction
TREML1 is a member of the triggering receptor expressed on myeloid cells-like (TREM) family. TREML1 is a type 1 single Ig domain orphan receptor localized to the alpha-granule membranes of platelets. TREML1 is involved in platelet aggregation, inflammation, and cellular activation and has been linked to Gray platelet syndrome.
Entrez Gene ID
340205
UniProt ID
Q86YW5
Alternative Names
Triggering Receptor Expressed On Myeloid Cells Like 1; Triggering Receptor Expressed On Myeloid Cells-Like Protein 1; TLT-1; TLT1; Triggering Receptor Expressed On Myeloid Cells-Like 1; Trem-Like Transcript 1 Protein
Function
Cell surface receptor that may play a role in the innate and adaptive immune response.
Biological Process
Biological Process calcium-mediated signaling Source:UniProtKB
Biological Process innate immune response Source:UniProtKB1 Publication
Biological Process platelet activation Source:UniProtKB1 Publication
Cellular Location
Cell membrane
Cytoplasm
Sequestered in cytoplasmic vesicles in resting platelets (PubMed:15100151).
Transported to the cell surface after stimulation by thrombin (PubMed:15100151).
Soluble fragments can be released into the serum by proteolysis (PubMed:16505478).
Topology
Extracellular: 16-162
Helical: 163-183
Cytoplasmic: 184-311
PTM
Phosphorylated on tyrosine residues.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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