Rat Anti-TREML1 Recombinant Antibody (CBYJT-4619) (CBMAB-T4148-YJ)

Name: Rat Anti-TREML1 Recombinant Antibody (CBYJT-4619)
SKU: CBMAB-T4148-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

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Basic Information

Host Animal

Rat

Clone

CBYJT-4619

Application

WB, FC, CyTOF

Immunogen

Mouse myeloma cell line NS0-derived recombinant human TREML1/TLT-1, Gln16-Ser160, Accession # Q86YW5

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, Trehalose

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 16-160

More Infomation

Target

Full Name

Triggering Receptor Expressed On Myeloid Cells-Like 1

Introduction

TREML1 is a member of the triggering receptor expressed on myeloid cells-like (TREM) family. TREML1 is a type 1 single Ig domain orphan receptor localized to the alpha-granule membranes of platelets. TREML1 is involved in platelet aggregation, inflammation, and cellular activation and has been linked to Gray platelet syndrome.

Entrez Gene ID

340205

UniProt ID

Q86YW5

Alternative Names

Triggering Receptor Expressed On Myeloid Cells Like 1; Triggering Receptor Expressed On Myeloid Cells-Like Protein 1; TLT-1; TLT1; Triggering Receptor Expressed On Myeloid Cells-Like 1; Trem-Like Transcript 1 Protein

Function

Cell surface receptor that may play a role in the innate and adaptive immune response.

Biological Process

Biological Process calcium-mediated signaling Source:UniProtKB
Biological Process innate immune response Source:UniProtKB1 Publication
Biological Process platelet activation Source:UniProtKB1 Publication

Cellular Location

Cell membrane
Cytoplasm
Sequestered in cytoplasmic vesicles in resting platelets (PubMed:15100151).
Transported to the cell surface after stimulation by thrombin (PubMed:15100151).
Soluble fragments can be released into the serum by proteolysis (PubMed:16505478).

Topology

Extracellular: 16-162
Helical: 163-183
Cytoplasmic: 184-311

PTM

Phosphorylated on tyrosine residues.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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