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Mouse Anti-TRPC5 Recombinant Antibody (1C8) (CBMAB-A9550-LY)

The product is antibody recognizes TRPC5. The antibody 1C8 immunoassay techniques such as: WB, ELISA.
See all TRPC5 antibodies
Published Data
Fig.1 Transient receptor potential canonical 5 (TRPC5) mRNA expression is regulated in the arthritic synovium; evidence that deletion exacerbates complete Freund's adjuvant (CFA)-induced arthritis.
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Fig.2 CirExo‐TRPC5 level was correlated with TRPC5 expression level in breast cancer tissues.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
1C8
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
TRPC5 (NP_036603, 534 a.a. ~ 603 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
transient receptor potential cation channel, subfamily C, member 5
Entrez Gene ID
7224
UniProt ID
Q9UL62
Alternative Names
TRP5
Function
Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective (By similarity).
May also be activated by intracellular calcium store depletion. Mediates calcium-dependent phosphatidylserine externalization and apoptosis in neurons via its association with PLSCR1 (By similarity).
Biological Process
Biological Process calcium ion transmembrane transport Source:GO_Central1 Publication
Biological Process calcium ion transport Source:ProtInc1 Publication
Biological Process manganese ion transport Source:GO_Central1 Publication
Biological Process negative regulation of dendrite morphogenesis Source:Ensembl
Biological Process nervous system development Source:ProtInc1 Publication
Biological Process neuron apoptotic process Source:UniProtKB
Biological Process neuron differentiation Source:Ensembl
Biological Process phosphatidylserine exposure on apoptotic cell surface Source:UniProtKB
Biological Process positive regulation of axon extension Source:Ensembl
Biological Process positive regulation of cell population proliferation Source:Ensembl
Biological Process positive regulation of cytosolic calcium ion concentration Source:Ensembl
Biological Process positive regulation of neuron differentiation Source:Ensembl
Biological Process positive regulation of peptidyl-threonine phosphorylation Source:Ensembl
Biological Process regulation of cytosolic calcium ion concentration Source:GO_Central1 Publication
Biological Process regulation of membrane hyperpolarization Source:Ensembl
Cellular Location
Cell membrane
Topology
Cytoplasmic: 1-330
Helical: 331-351
Extracellular: 352-398
Helical: 399-419
Cytoplasmic: 420-437
Helical: 438-458
Extracellular: 459-470
Helical: 471-491
Cytoplasmic: 492-512
Helical: 513-533
Extracellular: 534-603
Helical: 604-624
Cytoplasmic: 625-973
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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