TRPC5

TRPC5 belongs to the transient receptor family. It encodes one of the seven mammalian TRPC (transient receptor potential channel) proteins. TRPC5 is a multi-pass membrane protein and is thought to form a receptor-activated non-selective calcium permeant cation channel. The protein is active alone or as a heteromultimeric assembly with TRPC1, TRPC3, and TRPC4. TRPC5 also interacts with multiple proteins including calmodulin, CABP1, enkurin, Na(+)-H+ exchange regulatory factor (NHERF ), interferon-induced GTP-binding protein (MX1), ring finger protein 24 (RNF24), and SEC14 domain and spectrin repeat-containing protein 1 (SESTD1).

Full Name

transient receptor potential cation channel, subfamily C, member 5

Function

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective (By similarity).
May also be activated by intracellular calcium store depletion. Mediates calcium-dependent phosphatidylserine externalization and apoptosis in neurons via its association with PLSCR1 (By similarity).

Biological Process

Biological Process calcium ion transmembrane transport Source:GO_Central1 Publication
Biological Process calcium ion transport Source:ProtInc1 Publication
Biological Process manganese ion transport Source:GO_Central1 Publication
Biological Process negative regulation of dendrite morphogenesis Source:Ensembl
Biological Process nervous system development Source:ProtInc1 Publication
Biological Process neuron apoptotic process Source:UniProtKB
Biological Process neuron differentiation Source:Ensembl
Biological Process phosphatidylserine exposure on apoptotic cell surface Source:UniProtKB
Biological Process positive regulation of axon extension Source:Ensembl
Biological Process positive regulation of cell population proliferation Source:Ensembl
Biological Process positive regulation of cytosolic calcium ion concentration Source:Ensembl
Biological Process positive regulation of neuron differentiation Source:Ensembl
Biological Process positive regulation of peptidyl-threonine phosphorylation Source:Ensembl
Biological Process regulation of cytosolic calcium ion concentration Source:GO_Central1 Publication
Biological Process regulation of membrane hyperpolarization Source:Ensembl

Cellular Location

Cell membrane

Topology

Cytoplasmic: 1-330
Helical: 331-351
Extracellular: 352-398
Helical: 399-419
Cytoplasmic: 420-437
Helical: 438-458
Extracellular: 459-470
Helical: 471-491
Cytoplasmic: 492-512
Helical: 513-533
Extracellular: 534-603
Helical: 604-624
Cytoplasmic: 625-973