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Mouse Anti-TRPC5 Recombinant Antibody (CBYJT-4906) (CBMAB-T4454-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TRPC5 (Transient Receptor Potential Cation Channel Subfamily C Member 5). The antibody can be used for immunoassay techniques, such as WB, IHC-P, IF, ICC.
See all TRPC5 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBYJT-4906
Antibody Isotype
IgG2b
Application
WB, IHC-P, IF, ICC

Basic Information

Immunogen
Synthetic peptide amino acids 827-845 of human TrpC5, also known as short transient receptor potential channel 5, and Htrp5
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4, 50% Glycerol
Preservative
0.09% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 827-845

Target

Full Name
transient receptor potential cation channel, subfamily C, member 5
Introduction
TRPC5 belongs to the transient receptor family. It encodes one of the seven mammalian TRPC (transient receptor potential channel) proteins. TRPC5 is a multi-pass membrane protein and is thought to form a receptor-activated non-selective calcium permeant cation channel. The protein is active alone or as a heteromultimeric assembly with TRPC1, TRPC3, and TRPC4. TRPC5 also interacts with multiple proteins including calmodulin, CABP1, enkurin, Na(+)-H+ exchange regulatory factor (NHERF ), interferon-induced GTP-binding protein (MX1), ring finger protein 24 (RNF24), and SEC14 domain and spectrin repeat-containing protein 1 (SESTD1).
Entrez Gene ID
Human7224
Mouse22067
Rat140933
UniProt ID
HumanQ9UL62
MouseQ9QX29
RatQ8VD38
Alternative Names
Transient Receptor Potential Cation Channel Subfamily C Member 5; Protein Phosphatase 1, Regulatory Subunit 159; Transient Receptor Protein 5; TRP-5; HTRP5; TRP5; Transient Receptor Potential Cation Channel, Subfamily C, Member 5
Function
Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective (By similarity).
May also be activated by intracellular calcium store depletion. Mediates calcium-dependent phosphatidylserine externalization and apoptosis in neurons via its association with PLSCR1 (By similarity).
Biological Process
Biological Process calcium ion transmembrane transport Source:GO_Central1 Publication
Biological Process calcium ion transport Source:ProtInc1 Publication
Biological Process manganese ion transport Source:GO_Central1 Publication
Biological Process negative regulation of dendrite morphogenesis Source:Ensembl
Biological Process nervous system development Source:ProtInc1 Publication
Biological Process neuron apoptotic process Source:UniProtKB
Biological Process neuron differentiation Source:Ensembl
Biological Process phosphatidylserine exposure on apoptotic cell surface Source:UniProtKB
Biological Process positive regulation of axon extension Source:Ensembl
Biological Process positive regulation of cell population proliferation Source:Ensembl
Biological Process positive regulation of cytosolic calcium ion concentration Source:Ensembl
Biological Process positive regulation of neuron differentiation Source:Ensembl
Biological Process positive regulation of peptidyl-threonine phosphorylation Source:Ensembl
Biological Process regulation of cytosolic calcium ion concentration Source:GO_Central1 Publication
Biological Process regulation of membrane hyperpolarization Source:Ensembl
Cellular Location
Cell membrane
Topology
Cytoplasmic: 1-330
Helical: 331-351
Extracellular: 352-398
Helical: 399-419
Cytoplasmic: 420-437
Helical: 438-458
Extracellular: 459-470
Helical: 471-491
Cytoplasmic: 492-512
Helical: 513-533
Extracellular: 534-603
Helical: 604-624
Cytoplasmic: 625-973
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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