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Mouse Anti-TRPM7 (AA 1817-1863) Recombinant Antibody (CBFYC-3211) (CBMAB-C3288-FY)

This product is mouse antibody that recognizes TRPM7. The antibody CBFYC-3211 can be used for immunoassay techniques such as: ICC, IP, WB.
See all TRPM7 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBFYC-3211
Antibody Isotype
IgG1
Application
ICC, IP, WB

Basic Information

Immunogen
Fusion protein corresponding to aa1817-1863 (cytoplasmic C-terminus) of mouse TrpM7 (Q923J1)
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4, 50% glycerol
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1817-1863

Target

Full Name
Transient Receptor Potential Cation Channel, Subfamily M, Member 7
Introduction
This gene belongs to the melastatin subfamily of transient receptor potential family of ion channels. The protein encoded by this gene is both an ion channel and a serine/threonine protein kinase. The kinase activity is essential for the ion channel function, which serves to increase intracellular calcium levels and to help regulate magnesium ion homeostasis. The encoded protein is involved in cytoskeletal organization, cell adhesion, cell migration and organogenesis. Defects in this gene are a cause of amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam. The gene may also be associated with defects of cardiac function.
Entrez Gene ID
Human54822
Mouse58800
Rat679906
UniProt ID
HumanQ96QT4
MouseQ923J1
RatQ925B3
Alternative Names
Transient Receptor Potential Cation Channel Subfamily M Member 7; Long Transient Receptor Potential Channel 7; Channel-Kinase 1; EC 2.7.11.1; LTrpC-7; LTRPC7; CHAK1
Function
Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium (PubMed:35561741).
Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. Involved in TNF-induced necroptosis downstream of MLKL by mediating calcium influx. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1).
Biological Process
Biological Process actomyosin structure organization Source:Ensembl
Biological Process calcium ion transmembrane transport Source:Reactome
Biological Process calcium ion transport Source:GO_Central1 Publication
Biological Process calcium-dependent cell-matrix adhesion Source:Ensembl
Biological Process cation transmembrane transport Source:GO_Central1 Publication
Biological Process cellular magnesium ion homeostasis Source:InterPro
Biological Process divalent inorganic cation homeostasis Source:GO_Central1 Publication
Biological Process necroptotic process Source:UniProtKB1 Publication
Biological Process protein autophosphorylation Source:Ensembl
Biological Process protein tetramerization Source:InterPro
Cellular Location
Membrane
Involvement in disease
Amyotrophic lateral sclerosis-parkinsonism/dementia complex 1 (ALS-PDC1):
A neurodegenerative disorder characterized by chronic, progressive and uniformly fatal amyotrophic lateral sclerosis and parkinsonism-dementia. Both diseases are known to occur in the same kindred, the same sibship and even the same individual.
Topology
Cytoplasmic: 1-755
Helical: 756-776
Extracellular: 777-855
Helical: 856-876
Cytoplasmic: 877-918
Helical: 919-939
Extracellular: 940-962
Helical: 963-983
Cytoplasmic: 984-995
Helical: 996-1016
Extracellular: 1017-1035
Pore-forming: 1036-1056
Extracellular: 1057-1074
Helical: 1075-1095
Cytoplasmic: 1096-1865
PTM
Autophosphorylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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