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Rabbit Anti-TRPM7 Recombinant Antibody (BA0269) (CBMAB-0887CQ)

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Datasheet
SDS
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Basic Information

Host Animal
Rabbit
Clone
BA0269
Application
WB, FC, IF
Immunogen
Synthetic peptide against the residues close to the C-terminus of Human TRPM7
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
Transient Receptor Potential Cation Channel, Subfamily M, Member 7
Introduction
The protein encoded by this gene is both an ion channel and a serine/threonine protein kinase. Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. Involved in TNF-induced necroptosis downstream of MLKL by mediating calcium influx. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1).
Entrez Gene ID
Human54822
Mouse58800
Rat679906
UniProt ID
HumanQ96QT4
MouseQ923J1
RatQ925B3
Alternative Names
CHAK; CHAK1; ALSPDC; LTRPC7; LTrpC-7; TRP-PLIK
Function
Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium (PubMed:35561741).
Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. Involved in TNF-induced necroptosis downstream of MLKL by mediating calcium influx. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1).
Biological Process
Biological Process actomyosin structure organization Source:Ensembl
Biological Process calcium ion transmembrane transport Source:Reactome
Biological Process calcium ion transport Source:GO_Central1 Publication
Biological Process calcium-dependent cell-matrix adhesion Source:Ensembl
Biological Process cation transmembrane transport Source:GO_Central1 Publication
Biological Process cellular magnesium ion homeostasis Source:InterPro
Biological Process divalent inorganic cation homeostasis Source:GO_Central1 Publication
Biological Process necroptotic process Source:UniProtKB1 Publication
Biological Process protein autophosphorylation Source:Ensembl
Biological Process protein tetramerization Source:InterPro
Cellular Location
Membrane
Involvement in disease
Amyotrophic lateral sclerosis-parkinsonism/dementia complex 1 (ALS-PDC1):
A neurodegenerative disorder characterized by chronic, progressive and uniformly fatal amyotrophic lateral sclerosis and parkinsonism-dementia. Both diseases are known to occur in the same kindred, the same sibship and even the same individual.
Topology
Cytoplasmic: 1-755
Helical: 756-776
Extracellular: 777-855
Helical: 856-876
Cytoplasmic: 877-918
Helical: 919-939
Extracellular: 940-962
Helical: 963-983
Cytoplasmic: 984-995
Helical: 996-1016
Extracellular: 1017-1035
Pore-forming: 1036-1056
Extracellular: 1057-1074
Helical: 1075-1095
Cytoplasmic: 1096-1865
PTM
Autophosphorylated.
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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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