TRPM7

Trpm7 is an essential ion channel and serine/threonine-protein kinase. Trpm7 is a divalent cation channel permeable to calcium and magnesium. It has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. Trpm7 is involved in TNF-induced necroptosis downstream of MLKL by mediating calcium influx. The kinase activity is essential for the channel function. Trpm7 may be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. It phosphorylates annexin A1 (ANXA1).

Full Name

Transient Receptor Potential Cation Channel, Subfamily M, Member 7

Function

Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium (PubMed:35561741).
Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. Involved in TNF-induced necroptosis downstream of MLKL by mediating calcium influx. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1).

Biological Process

Biological Process actomyosin structure organization Source:Ensembl
Biological Process calcium ion transmembrane transport Source:Reactome
Biological Process calcium ion transport Source:GO_Central1 Publication
Biological Process calcium-dependent cell-matrix adhesion Source:Ensembl
Biological Process cation transmembrane transport Source:GO_Central1 Publication
Biological Process cellular magnesium ion homeostasis Source:InterPro
Biological Process divalent inorganic cation homeostasis Source:GO_Central1 Publication
Biological Process necroptotic process Source:UniProtKB1 Publication
Biological Process protein autophosphorylation Source:Ensembl
Biological Process protein tetramerization Source:InterPro

Cellular Location

Membrane

Involvement in disease

Amyotrophic lateral sclerosis-parkinsonism/dementia complex 1 (ALS-PDC1):
A neurodegenerative disorder characterized by chronic, progressive and uniformly fatal amyotrophic lateral sclerosis and parkinsonism-dementia. Both diseases are known to occur in the same kindred, the same sibship and even the same individual.

Topology

Cytoplasmic: 1-755
Helical: 756-776
Extracellular: 777-855
Helical: 856-876
Cytoplasmic: 877-918
Helical: 919-939
Extracellular: 940-962
Helical: 963-983
Cytoplasmic: 984-995
Helical: 996-1016
Extracellular: 1017-1035
Pore-forming: 1036-1056
Extracellular: 1057-1074
Helical: 1075-1095
Cytoplasmic: 1096-1865

PTM

Autophosphorylated.