TRPM7

Trpm7 is an essential ion channel and serine/threonine-protein kinase. Trpm7 is a divalent cation channel permeable to calcium and magnesium. It has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. Trpm7 is involved in TNF-induced necroptosis downstream of MLKL by mediating calcium influx. The kinase activity is essential for the channel function. Trpm7 may be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. It phosphorylates annexin A1 (ANXA1).

Transient Receptor Potential Cation Channel, Subfamily M, Member 7

Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium (PubMed:35561741).
Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. Involved in TNF-induced necroptosis downstream of MLKL by mediating calcium influx. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1).

Biological Process actomyosin structure organization Source:Ensembl
Biological Process calcium ion transmembrane transport Source:Reactome
Biological Process calcium ion transport Source:GO_Central1 Publication
Biological Process calcium-dependent cell-matrix adhesion Source:Ensembl
Biological Process cation transmembrane transport Source:GO_Central1 Publication
Biological Process cellular magnesium ion homeostasis Source:InterPro
Biological Process divalent inorganic cation homeostasis Source:GO_Central1 Publication
Biological Process necroptotic process Source:UniProtKB1 Publication
Biological Process protein autophosphorylation Source:Ensembl
Biological Process protein tetramerization Source:InterPro

Membrane

Amyotrophic lateral sclerosis-parkinsonism/dementia complex 1 (ALS-PDC1):
A neurodegenerative disorder characterized by chronic, progressive and uniformly fatal amyotrophic lateral sclerosis and parkinsonism-dementia. Both diseases are known to occur in the same kindred, the same sibship and even the same individual.

Cytoplasmic: 1-755
Helical: 756-776
Extracellular: 777-855
Helical: 856-876
Cytoplasmic: 877-918
Helical: 919-939
Extracellular: 940-962
Helical: 963-983
Cytoplasmic: 984-995
Helical: 996-1016
Extracellular: 1017-1035
Pore-forming: 1036-1056
Extracellular: 1057-1074
Helical: 1075-1095
Cytoplasmic: 1096-1865

Autophosphorylated.