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Mouse Anti-Trpm7 Recombinant Antibody (S74-25) (CBMAB-T4472-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to Trpm7 (Transient Receptor Potential Cation Channel, Subfamily M, Member 7). The antibody can be used for immunoassay techniques, such as WB, IHC, ICC, IF, AM.
See all Trpm7 antibodies
Published Data
Fig.1 Expression of TRPM7 in Ovarian Carcinomas.
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Fig.2 Effect of C(60)HyFn administration of TRPM2 and TRPM7 ion channels in total brain homogenate of control, HHcy, HHcy + C(60)HyFn and C(60)HyFn groups.
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Fig.3 The immunohistochemistry staining of TRPM7 ion channel in brain slices of control, HHcy, HHcy + C(60)HyFn and C(60)HyFn groups.
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Summary

Host Animal
Mouse
Specificity
Mouse, Human, Rat
Clone
S74-25
Antibody Isotype
IgG1
Application
WB, IHC, ICC, IF, AM

Basic Information

Immunogen
Fusion protein amino acids 1817-1863 (C- terminus) of mouse TrpM7
Specificity
Mouse, Human, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1817-1863

Target

Full Name
Transient Receptor Potential Cation Channel, Subfamily M, Member 7
Introduction
Trpm7 is an essential ion channel and serine/threonine-protein kinase. Trpm7 is a divalent cation channel permeable to calcium and magnesium. It has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. Trpm7 is involved in TNF-induced necroptosis downstream of MLKL by mediating calcium influx. The kinase activity is essential for the channel function. Trpm7 may be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. It phosphorylates annexin A1 (ANXA1).
Entrez Gene ID
Human54822
Mouse58800
Rat679906
UniProt ID
HumanQ96QT4
MouseQ923J1
RatQ925B3
Alternative Names
CHAK; CHAK1; Ltpr7; Ltrpc7; LTrpC-7; TRPPLIK; 2310022G15Rik; 4833414K03Rik; 5033407O22Rik
Function
Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium (PubMed:35561741).
Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. Involved in TNF-induced necroptosis downstream of MLKL by mediating calcium influx. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1).
Biological Process
Biological Process actomyosin structure organization Source:Ensembl
Biological Process calcium ion transmembrane transport Source:Reactome
Biological Process calcium ion transport Source:GO_Central1 Publication
Biological Process calcium-dependent cell-matrix adhesion Source:Ensembl
Biological Process cation transmembrane transport Source:GO_Central1 Publication
Biological Process cellular magnesium ion homeostasis Source:InterPro
Biological Process divalent inorganic cation homeostasis Source:GO_Central1 Publication
Biological Process necroptotic process Source:UniProtKB1 Publication
Biological Process protein autophosphorylation Source:Ensembl
Biological Process protein tetramerization Source:InterPro
Cellular Location
Membrane
Involvement in disease
Amyotrophic lateral sclerosis-parkinsonism/dementia complex 1 (ALS-PDC1):
A neurodegenerative disorder characterized by chronic, progressive and uniformly fatal amyotrophic lateral sclerosis and parkinsonism-dementia. Both diseases are known to occur in the same kindred, the same sibship and even the same individual.
Topology
Cytoplasmic: 1-755
Helical: 756-776
Extracellular: 777-855
Helical: 856-876
Cytoplasmic: 877-918
Helical: 919-939
Extracellular: 940-962
Helical: 963-983
Cytoplasmic: 984-995
Helical: 996-1016
Extracellular: 1017-1035
Pore-forming: 1036-1056
Extracellular: 1057-1074
Helical: 1075-1095
Cytoplasmic: 1096-1865
PTM
Autophosphorylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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