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Mouse Anti-TTL Recombinant Antibody (CBYJT-5158) (CBMAB-T4736-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TTL (Tubulin Tyrosine Ligase). The antibody can be used for immunoassay techniques, such as ELISA.
See all TTL antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-5158
Antibody Isotype
IgG2a, κ
Application
ELISA

Basic Information

Immunogen
Partial recombinant protein corresponding to aa279-378 from human TTL (NP_714923) with GST tag. MW of the GST tag alone is 26kD
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 279-378

Target

Full Name
TTL Tubulin Tyrosine Ligase
Introduction
TTL is a cytosolic enzyme involved in the posttranslational modification of alpha-tubulin. Alpha-tubulin within assembled microtubules is detyrosinated over time at the C terminus. After microtubule disassembly, TTL restores the tyrosine residues and consequently participates in a cycle of tubulin detyrosination and tyrosination (Erck et al., 2003 [PubMed 14571137]).
Entrez Gene ID
150465
UniProt ID
Q8NG68
Alternative Names
Tubulin Tyrosine Ligase; EC 6.3.2.25; Tubulin--Tyrosine Ligase; 2410003M22Rik
Function
Catalyzes the post-translational addition of a tyrosine to the C-terminal end of detyrosinated alpha-tubulin.
Biological Process
Biological Process microtubule cytoskeleton organization Source:GO_Central1 Publication
Biological Process positive regulation of mitotic cell cycle Source:UniProtKB1 Publication
Biological Process post-translational protein modification Source:UniProtKB1 Publication
Biological Process regulation of axon extension Source:Ensembl
Biological Process regulation of metaphase plate congression Source:UniProtKB1 Publication
Cellular Location
Spindle microtubule
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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