Mouse Anti-TTL Recombinant Antibody (CBYJT-5159) (CBMAB-T4737-YJ)

Name: Mouse Anti-TTL Recombinant Antibody (CBYJT-5159)
SKU: CBMAB-T4737-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBYJT-5159

Application

Immunogen

Full length human recombinant protein of human TTL (NP_714923) produced in HEK293T cell

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

TTL Tubulin Tyrosine Ligase

Introduction

TTL is a cytosolic enzyme involved in the posttranslational modification of alpha-tubulin. Alpha-tubulin within assembled microtubules is detyrosinated over time at the C terminus. After microtubule disassembly, TTL restores the tyrosine residues and consequently participates in a cycle of tubulin detyrosination and tyrosination (Erck et al., 2003 [PubMed 14571137]).

Entrez Gene ID

150465

UniProt ID

Q8NG68

Alternative Names

Tubulin Tyrosine Ligase; EC 6.3.2.25; Tubulin--Tyrosine Ligase; 2410003M22Rik

Function

Catalyzes the post-translational addition of a tyrosine to the C-terminal end of detyrosinated alpha-tubulin.

Biological Process

Biological Process microtubule cytoskeleton organization Source:GO_Central1 Publication
Biological Process positive regulation of mitotic cell cycle Source:UniProtKB1 Publication
Biological Process post-translational protein modification Source:UniProtKB1 Publication
Biological Process regulation of axon extension Source:Ensembl
Biological Process regulation of metaphase plate congression Source:UniProtKB1 Publication

Cellular Location

Spindle microtubule

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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