TTL

TTL is a cytosolic enzyme involved in the posttranslational modification of alpha-tubulin (see MIM 602529). Alpha-tubulin within assembled microtubules is detyrosinated over time at the C terminus. After microtubule disassembly, TTL restores the tyrosine residues and consequently participates in a cycle of tubulin detyrosination and tyrosination (Erck et al., 2003 [PubMed 14571137]).[supplied by OMIM, Mar 2008]

TTL Tubulin Tyrosine Ligase

Catalyzes the post-translational addition of a tyrosine to the C-terminal end of detyrosinated alpha-tubulin.

Biological Process microtubule cytoskeleton organization Source:GO_Central1 Publication
Biological Process positive regulation of mitotic cell cycle Source:UniProtKB1 Publication
Biological Process post-translational protein modification Source:UniProtKB1 Publication
Biological Process regulation of axon extension Source:Ensembl
Biological Process regulation of metaphase plate congression Source:UniProtKB1 Publication

Spindle microtubule