TTL

TTL is a cytosolic enzyme involved in the posttranslational modification of alpha-tubulin (see MIM 602529). Alpha-tubulin within assembled microtubules is detyrosinated over time at the C terminus. After microtubule disassembly, TTL restores the tyrosine residues and consequently participates in a cycle of tubulin detyrosination and tyrosination (Erck et al., 2003 [PubMed 14571137]).[supplied by OMIM, Mar 2008]
Full Name
TTL Tubulin Tyrosine Ligase
Function
Catalyzes the post-translational addition of a tyrosine to the C-terminal end of detyrosinated alpha-tubulin.
Biological Process
Biological Process microtubule cytoskeleton organization Source:GO_Central1 Publication
Biological Process positive regulation of mitotic cell cycle Source:UniProtKB1 Publication
Biological Process post-translational protein modification Source:UniProtKB1 Publication
Biological Process regulation of axon extension Source:Ensembl
Biological Process regulation of metaphase plate congression Source:UniProtKB1 Publication
Cellular Location
Spindle microtubule
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Anti-TTL antibodies

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Mouse Anti-TTL Recombinant Antibody (1B2) (CBMAB-A9613-LY)

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Target: TTL
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1B2
Application*: SE, E
Datasheet SDS

Mouse Anti-TTL Recombinant Antibody (CBYJT-5160) (CBMAB-T4738-YJ)

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Target: TTL
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Pig, Rat
Clone: CBYJT-5160
Application*: E, IH, WB
Datasheet SDS

Mouse Anti-TTL Recombinant Antibody (CBYJT-5159) (CBMAB-T4737-YJ)

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Target: TTL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-5159
Application*: WB
Datasheet SDS

Mouse Anti-TTL Recombinant Antibody (CBYJT-5158) (CBMAB-T4736-YJ)

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Target: TTL
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJT-5158
Application*: E
Datasheet SDS

Mouse Anti-TTL Recombinant Antibody (CF458) (CBMAB-FT065LY)

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Target: TTL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CF458
Application*: ELISA, WB, IHC
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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