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Mouse Anti-TTL Recombinant Antibody (CF458) (CBMAB-FT065LY)

The product is antibody recognizes TTL . The antibody CF458 immunoassay techniques such as: ELISA, WB, IHC.
See all TTL antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CF458
Antibody Isotype
IgG1
Application
ELISA, WB, IHC

Basic Information

Immunogen
tubulin tyrosine ligase
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50% glycerol
Preservative
0.02% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
TTL Tubulin Tyrosine Ligase
Introduction
TTL is a cytosolic enzyme involved in the posttranslational modification of alpha-tubulin (see MIM 602529). Alpha-tubulin within assembled microtubules is detyrosinated over time at the C terminus. After microtubule disassembly, TTL restores the tyrosine residues and consequently participates in a cycle of tubulin detyrosination and tyrosination (Erck et al., 2003 [PubMed 14571137]).[supplied by OMIM, Mar 2008]
Entrez Gene ID
150465
UniProt ID
Q8NG68
Alternative Names
TTL, tubulin tyrosine ligase, Tubulin tyrosine ligase
Function
Catalyzes the post-translational addition of a tyrosine to the C-terminal end of detyrosinated alpha-tubulin.
Biological Process
Biological Process microtubule cytoskeleton organization Source:GO_Central1 Publication
Biological Process positive regulation of mitotic cell cycle Source:UniProtKB1 Publication
Biological Process post-translational protein modification Source:UniProtKB1 Publication
Biological Process regulation of axon extension Source:Ensembl
Biological Process regulation of metaphase plate congression Source:UniProtKB1 Publication
Cellular Location
Spindle microtubule
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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