Rabbit Anti-TXNIP Recombinant Antibody (D5F3E) (CBMAB-CP2904-LY)

Name: Rabbit Anti-TXNIP Recombinant Antibody (D5F3E)
SKU: CBMAB-CP2904-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

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Basic Information

Host Animal

Rabbit

Clone

D5F3E

Application

WB, IP

Immunogen

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val337 of human TXNIP protein.

Specificity

Human, Mouse, Rat, Monkey

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

100 µg/ml BSA, 50% glycerol

Preservative

0.02% sodium azide

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

TXNIP Gene(Protein Coding) Thioredoxin Interacting Protein

Introduction

This gene encodes a thioredoxin-binding protein that is a member of the alpha arrestin protein family. Thioredoxin is a thiol-oxidoreductase that is a major regulator of cellular redox signaling which protects cells from oxidative stress. This protein inhibits the antioxidative function of thioredoxin resulting in the accumulation of reactive oxygen species and cellular stress. This protein also functions as a regulator of cellular metabolism and of endoplasmic reticulum (ER) stress. This protein may also function as a tumor suppressor. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Entrez Gene ID

Human	10628
Mouse	56338
Rat	117514
Monkey	698683

UniProt ID

Human	Q9H3M7
Mouse	Q8BG60
Rat	Q5M7W1
Monkey	F7EDN0

Alternative Names

Thioredoxin Interacting Protein; Upregulated By 1;25-Dihydroxyvitamin D-3; Vitamin D3 Up-Regulated Protein 1; Thioredoxin Binding Protein 2; VDUP1; Thioredoxin-Interacting Protein;

Function

May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1).

Biological Process

Biological Process cell cycle Source:UniProtKB-KW
Biological Process cellular response to tumor cell Source:UniProtKB1 Publication
Biological Process keratinocyte differentiation Source:UniProtKB1 Publication
Biological Process negative regulation of cell division Source:UniProtKB1 Publication
Biological Process negative regulation of transcription by RNA polymerase II Source:Ensembl
Biological Process platelet-derived growth factor receptor signaling pathway Source:Ensembl
Biological Process positive regulation of apoptotic process Source:Ensembl
Biological Process protein import into nucleus Source:Ensembl
Biological Process protein transport Source:GO_Central1 Publication
Biological Process regulation of cell population proliferation Source:Ensembl
Biological Process response to calcium ion Source:Ensembl
Biological Process response to estradiol Source:Ensembl
Biological Process response to glucose Source:Ensembl
Biological Process response to hydrogen peroxide Source:Ensembl
Biological Process response to mechanical stimulus Source:Ensembl
Biological Process response to progesterone Source:Ensembl
Biological Process response to xenobiotic stimulus Source:Ensembl

Cellular Location

Cytoplasm

PTM

Ubiquitinated; undergoes polyubiquitination catalyzed by ITCH resulting in proteasomal degradation.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-TXNIP Recombinant Antibody (JY1) (CAT#: CBMAB-T5084-YJ)

Mouse Anti-TXNIP Recombinant Antibody (JY2) (CAT#: CBMAB-T5085-YJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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