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Mouse Anti-TXNIP Recombinant Antibody (JY2) (CBMAB-T5085-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TXNIP (Thioredoxin Interacting Protein). The antibody can be used for immunoassay techniques, such as WB, IP, IHC-P, PLA.
See all TXNIP antibodies
Published Data
Fig.1 K5 increases the expression of TXNIP.
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Fig.2 Representative serial sections of stained case-matched normal esophageal epithelium and ESCC tissue specimens for TXNIP.
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Fig.3 Subcellular localization of Trx and its associated proteins TXNIP was analyzed by immunofluorescence stainings.
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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
JY2
Antibody Isotype
IgG1
Application
WB, IP, IHC-P, PLA

Basic Information

Immunogen
Human recombinant TXNIP
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TXNIP Gene(Protein Coding) Thioredoxin Interacting Protein
Introduction
TXNIP is a thioredoxin-binding protein that is a member of the alpha arrestin protein family. Thioredoxin is a thiol-oxidoreductase that is a major regulator of cellular redox signaling which protects cells from oxidative stress. TXNIP inhibits the antioxidative function of thioredoxin resulting in the accumulation of reactive oxygen species and cellular stress. TXNIP also plays a role as a regulator of cellular metabolism and of endoplasmic reticulum (ER) stress. TXNIP may also play a role as a tumor suppressor.
Entrez Gene ID
Human10628
Mouse56338
Rat117514
UniProt ID
HumanQ9H3M7
MouseQ8BG60
RatQ5M7W1
Alternative Names
Thioredoxin Interacting Protein; Upregulated By 1, 25-Dihydroxyvitamin D-3; Vitamin D3 Up-Regulated Protein 1; Thioredoxin Binding Protein 2; VDUP1; Thioredoxin-Interacting Protein
Function
May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1).
Biological Process
Biological Process cell cycle Source:UniProtKB-KW
Biological Process cellular response to tumor cell Source:UniProtKB1 Publication
Biological Process keratinocyte differentiation Source:UniProtKB1 Publication
Biological Process negative regulation of cell division Source:UniProtKB1 Publication
Biological Process negative regulation of transcription by RNA polymerase II Source:Ensembl
Biological Process platelet-derived growth factor receptor signaling pathway Source:Ensembl
Biological Process positive regulation of apoptotic process Source:Ensembl
Biological Process protein import into nucleus Source:Ensembl
Biological Process protein transport Source:GO_Central1 Publication
Biological Process regulation of cell population proliferation Source:Ensembl
Biological Process response to calcium ion Source:Ensembl
Biological Process response to estradiol Source:Ensembl
Biological Process response to glucose Source:Ensembl
Biological Process response to hydrogen peroxide Source:Ensembl
Biological Process response to mechanical stimulus Source:Ensembl
Biological Process response to progesterone Source:Ensembl
Biological Process response to xenobiotic stimulus Source:Ensembl
Cellular Location
Cytoplasm
PTM
Ubiquitinated; undergoes polyubiquitination catalyzed by ITCH resulting in proteasomal degradation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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