TXNIP

Full Name

TXNIP Gene(Protein Coding) Thioredoxin Interacting Protein

Function

May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1).

Biological Process

Biological Process cell cycle Source:UniProtKB-KW
Biological Process cellular response to tumor cell Source:UniProtKB1 Publication
Biological Process keratinocyte differentiation Source:UniProtKB1 Publication
Biological Process negative regulation of cell division Source:UniProtKB1 Publication
Biological Process negative regulation of transcription by RNA polymerase II Source:Ensembl
Biological Process platelet-derived growth factor receptor signaling pathway Source:Ensembl
Biological Process positive regulation of apoptotic process Source:Ensembl
Biological Process protein import into nucleus Source:Ensembl
Biological Process protein transport Source:GO_Central1 Publication
Biological Process regulation of cell population proliferation Source:Ensembl
Biological Process response to calcium ion Source:Ensembl
Biological Process response to estradiol Source:Ensembl
Biological Process response to glucose Source:Ensembl
Biological Process response to hydrogen peroxide Source:Ensembl
Biological Process response to mechanical stimulus Source:Ensembl
Biological Process response to progesterone Source:Ensembl
Biological Process response to xenobiotic stimulus Source:Ensembl

Cellular Location

Cytoplasm

PTM

Ubiquitinated; undergoes polyubiquitination catalyzed by ITCH resulting in proteasomal degradation.