Sign in or Register   Sign in or Register
  |  

Mouse Anti-UBE2D2 Recombinant Antibody (4A1) (CBMAB-A9705-LY)

The product is antibody recognizes UBE2D2. The antibody 4A1 immunoassay techniques such as: WB, ELISA.
See all UBE2D2 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
4A1
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
UBE2D2 (NP_003330, 1 a.a. ~ 94 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)
Introduction
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase. Two alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms. [provided by RefSeq]
Entrez Gene ID
Human7322
Mouse56550
Rat641452
UniProt ID
HumanP62837
MouseP62838
RatP62839
Alternative Names
E2(17)KB2; PUBC1; UBC4; UBC4/5; UBCH5B
Function
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by RIGI in response to viral infection. Essential for viral activation of IRF3.
Biological Process
Biological Process protein autoubiquitination Source:ParkinsonsUK-UCL1 Publication
Biological Process protein K48-linked ubiquitination Source:UniProtKB1 Publication
Biological Process protein modification process Source:ProtInc1 Publication
Biological Process protein polyubiquitination Source:BHF-UCL1 Publication
Biological Process protein ubiquitination Source:ParkinsonsUK-UCL2 Publications
Biological Process ubiquitin-dependent protein catabolic process Source:ProtInc1 Publication
Cellular Location
cytosol
extracellular exosome
nucleoplasm
nucleus
protein-containing complex
ubiquitin ligase complex
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-UBE2D2 Recombinant Antibody (4A1)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare