UBE2D2

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase. Two alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms. [provided by RefSeq]
Full Name
ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)
Function
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by RIGI in response to viral infection. Essential for viral activation of IRF3.
Biological Process
Biological Process protein autoubiquitination Source:ParkinsonsUK-UCL1 Publication
Biological Process protein K48-linked ubiquitination Source:UniProtKB1 Publication
Biological Process protein modification process Source:ProtInc1 Publication
Biological Process protein polyubiquitination Source:BHF-UCL1 Publication
Biological Process protein ubiquitination Source:ParkinsonsUK-UCL2 Publications
Biological Process ubiquitin-dependent protein catabolic process Source:ProtInc1 Publication
Cellular Location
cytosol
extracellular exosome
nucleoplasm
nucleus
protein-containing complex
ubiquitin ligase complex
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Anti-UBE2D2 antibodies

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Mouse Anti-UBE2D2 Recombinant Antibody (4A1) (CBMAB-A9705-LY)

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Target: UBE2D2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: 4A1
Application*: WB, E
Datasheet SDS

Xenopus Recombinant UBE2D2, Active protein, His Tag (V2LY-0526-LY9850)

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Target: UBE2D2
Expressed Host: E. coli
Sequence: Amino Acid: Full Length
Tag: His Tag
Datasheet SDS

Mouse Anti-UBE2D2 Recombinant Antibody (CBFYU-088) (CBMAB-U0088-FY)

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Target: UBE2D2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYU-088
Application*: WB, IH
Datasheet SDS

Mouse Anti-UBE2D2 Recombinant Antibody (CBFYU-087) (CBMAB-U0087-FY)

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Target: UBE2D2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Mouse, Human
Clone: CBFYU-087
Application*: WB
Datasheet SDS

Mouse Anti-UBE2D2 Recombinant Antibody (CBFYU-086) (CBMAB-U0086-FY)

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Target: UBE2D2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYU-086
Application*: P, WB
Datasheet SDS

Mouse Anti-UBE2D2 Recombinant Antibody (CBFYU-085) (CBMAB-U0085-FY)

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Target: UBE2D2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYU-085
Application*: P
Datasheet SDS

Mouse Anti-UBE2D2 Recombinant Antibody (CBFYU-084) (CBMAB-U0084-FY)

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Target: UBE2D2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: CBFYU-084
Application*: E, P, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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