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UBE2D2

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase. Two alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms. [provided by RefSeq]

Full Name

ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)

Function

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by RIGI in response to viral infection. Essential for viral activation of IRF3.

Biological Process

Biological Process protein autoubiquitination Source:ParkinsonsUK-UCL1 Publication
Biological Process protein K48-linked ubiquitination Source:UniProtKB1 Publication
Biological Process protein modification process Source:ProtInc1 Publication
Biological Process protein polyubiquitination Source:BHF-UCL1 Publication
Biological Process protein ubiquitination Source:ParkinsonsUK-UCL2 Publications
Biological Process ubiquitin-dependent protein catabolic process Source:ProtInc1 Publication

Cellular Location

cytosol
extracellular exosome
nucleoplasm
nucleus
protein-containing complex
ubiquitin ligase complex

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Anti-UBE2D2 antibodies

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Mouse Anti-UBE2D2 Recombinant Antibody (4A1) (CBMAB-A9705-LY)

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Target: UBE2D2

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human, Mouse, Rat

Clone: 4A1

Application*: WB, E

Xenopus Recombinant UBE2D2, Active protein, His Tag (V2LY-0526-LY9850)

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Target: UBE2D2

Expressed Host: E. coli

Sequence: Amino Acid: Full Length

Tag: His Tag

Mouse Anti-UBE2D2 Recombinant Antibody (CBFYU-088) (CBMAB-U0088-FY)

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Target: UBE2D2

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBFYU-088

Application*: WB, IH

Mouse Anti-UBE2D2 Recombinant Antibody (CBFYU-087) (CBMAB-U0087-FY)

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Target: UBE2D2

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Mouse, Human

Clone: CBFYU-087

Application*: WB

Mouse Anti-UBE2D2 Recombinant Antibody (CBFYU-086) (CBMAB-U0086-FY)

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Target: UBE2D2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYU-086

Application*: P, WB

Mouse Anti-UBE2D2 Recombinant Antibody (CBFYU-085) (CBMAB-U0085-FY)

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Target: UBE2D2

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBFYU-085

Application*: P

Mouse Anti-UBE2D2 Recombinant Antibody (CBFYU-084) (CBMAB-U0084-FY)

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Target: UBE2D2

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human, Mouse, Rat

Clone: CBFYU-084

Application*: E, P, WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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