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Mouse Anti-UBE2D2 Recombinant Antibody (CBFYU-084) (CBMAB-U0084-FY)

This product is mouse antibody that recognizes UBE2D2. The antibody CBFYU-084 can be used for immunoassay techniques such as: ELISA, IHC-P, WB.
See all UBE2D2 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBFYU-084
Antibody Isotype
IgG2a, к
Application
ELISA, IHC-P, WB

Basic Information

Immunogen
Recombinant protein with GST tag. MW of the GST tag alone is 26 kD.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2a, к
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Concentration
0.44 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1-95

Target

Full Name
ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)
Introduction
This gene encodes a member of the E2 enzyme family.
Entrez Gene ID
Human7322
Mouse56550
Rat641452
UniProt ID
HumanP62837
MouseP62838
RatP62839
Alternative Names
UBC4; PUBC1; UBCH4; UBC4/5; UBCH5B; E2(17)KB2
Function
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by RIGI in response to viral infection. Essential for viral activation of IRF3.
Biological Process
Biological Process protein autoubiquitination Source:ParkinsonsUK-UCL1 Publication
Biological Process protein K48-linked ubiquitination Source:UniProtKB1 Publication
Biological Process protein modification process Source:ProtInc1 Publication
Biological Process protein polyubiquitination Source:BHF-UCL1 Publication
Biological Process protein ubiquitination Source:ParkinsonsUK-UCL2 Publications
Biological Process ubiquitin-dependent protein catabolic process Source:ProtInc1 Publication
Cellular Location
cytosol
extracellular exosome
nucleoplasm
nucleus
protein-containing complex
ubiquitin ligase complex
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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