Mouse Anti-UBE2D2 Recombinant Antibody (CBFYU-088) (CBMAB-U0088-FY)

Name: Mouse Anti-UBE2D2 Recombinant Antibody (CBFYU-088)
SKU: CBMAB-U0088-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

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Basic Information

Host Animal

Mouse

Clone

CBFYU-088

Application

WB, IHC

Immunogen

Full length human recombinant protein of human UBE2D2 (NP_003330) produced in E.coli

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Concentration

1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)

Introduction

Regulated degradation of misfolded, damaged or short-lived proteins in eukaryotes occurs via the ubiquitin (Ub)-proteasome system (UPS). Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6.

Entrez Gene ID

7322

UniProt ID

P62837

Alternative Names

UBC4; PUBC1; UBCH4; UBC4/5; UBCH5B; E2(17)KB2

Function

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by RIGI in response to viral infection. Essential for viral activation of IRF3.

Biological Process

Biological Process protein autoubiquitination Source:ParkinsonsUK-UCL1 Publication
Biological Process protein K48-linked ubiquitination Source:UniProtKB1 Publication
Biological Process protein modification process Source:ProtInc1 Publication
Biological Process protein polyubiquitination Source:BHF-UCL1 Publication
Biological Process protein ubiquitination Source:ParkinsonsUK-UCL2 Publications
Biological Process ubiquitin-dependent protein catabolic process Source:ProtInc1 Publication

Cellular Location

cytosol
extracellular exosome
nucleoplasm
nucleus
protein-containing complex
ubiquitin ligase complex

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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