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Mouse Anti-UFD1 Recombinant Antibody (3A12) (CBMAB-C4517-CN)

This product is a Mouse antibody that recognizes UFD1. The antibody 3A12 can be used for immunoassay techniques such as: WB.
See all UFD1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3A12
Antibody Isotype
IgG3
Application
WB

Basic Information

Specificity
Human
Antibody Isotype
IgG3
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% Sodium azide
Concentration
1 mg/mL

Target

Full Name
Ubiquitin Recognition Factor In ER Associated Degradation 1
Introduction
The protein encoded by this gene forms a complex with two other proteins, nuclear protein localization-4 and valosin-containing protein, and this complex is necessary for the degradation of ubiquitinated proteins. In addition, this complex controls the disassembly of the mitotic spindle and the formation of a closed nuclear envelope after mitosis. Mutations in this gene have been associated with Catch 22 syndrome as well as cardiac and craniofacial defects. Alternative splicing results in multiple transcript variants encoding different isoforms. A related pseudogene has been identified on chromosome 18. [provided by RefSeq, Jun 2009]
Entrez Gene ID
7353
UniProt ID
Q92890
Alternative Names
Ubiquitin Recognition Factor In ER Associated Degradation 1; UB Fusion Protein 1; UFD1L; Ubiquitin Recognition Factor In ER-Associated Degradation Protein 1; Ubiquitin Fusion Degradation Protein 1 Homolog; Ubiquitin Fusion Degradation 1 Like (Yeast); Ubiquitin Fusion Degradation Protein 1; Ubiquitin Fusion Degradation 1-Like; Ubiquitin Fusion Degradation 1 Like;
Function
Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures (By similarity).
Acts as a negative regulator of type I interferon production via the complex formed with VCP and NPLOC4, which binds to RIGI and recruits RNF125 to promote ubiquitination and degradation of RIGI (PubMed:26471729).
Biological Process
Biological Process ER-associated misfolded protein catabolic process Source:ParkinsonsUK-UCL1 Publication
Biological Process negative regulation of RIG-I signaling pathway Source:UniProtKB1 Publication
Biological Process negative regulation of type I interferon production Source:UniProtKB1 Publication
Biological Process retrograde protein transport, ER to cytosol Source:ParkinsonsUK-UCL1 Publication
Biological Process skeletal system development Source:ProtInc1 Publication
Biological Process ubiquitin-dependent ERAD pathway Source:ComplexPortal
Biological Process ubiquitin-dependent protein catabolic process Source:UniProtKB1 Publication
Cellular Location
Nucleus
Cytoplasm, cytosol
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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