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Recombinant Mouse Anti-Ufd1 Recombinant Antibody (5E2) (CBMAB-XB1200-YC)

Provided herein is a Mouse Recombinant Antibody against Ubiquitin Recognition Factor In ER Associated Degradation 1. The antibody can be used for immunoassay techniques, such as ELISA, IF, IP, WB.
See all Ufd1 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Human, Rat, Frog
Clone
5E2
Antibody Isotype
IgG2a
Application
ELISA, IF, IP, WB

Basic Information

Immunogen
Full length mouse Ufd1 expressed in E. coli
Specificity
Mouse, Human, Rat, Frog
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Ubiquitin Recognition Factor In ER Associated Degradation 1
Introduction
Ufd1 forms a complex with two other proteins, nuclear protein localization-4 and valosin-containing protein, and this complex is necessary for the degradation of ubiquitinated proteins. In addition, this complex controls the disassembly of the mitotic spindle and the formation of a closed nuclear envelope after mitosis.
Entrez Gene ID
Human7353
Mouse22230
Rat84478
Frog448516
UniProt ID
HumanQ92890
MouseP70362
RatQ9ES53
FrogF6TDH6
Alternative Names
Ubiquitin Recognition Factor In ER Associated Degradation 1; UB Fusion Protein 1; UFD1L; Ubiquitin Recognition Factor In ER-Associated Degradation Protein 1; Ubiquitin Fusion Degradation Protein 1 Homolog; Ubiquitin Fusion Degradation 1 Like (Yeast); Ubiquitin Fusion Degradation Protein 1; Ubiquitin Fusion Degradation 1-Like; Ubiquitin Fusion Degradation 1 Like;
Function
Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures (By similarity).
Acts as a negative regulator of type I interferon production via the complex formed with VCP and NPLOC4, which binds to RIGI and recruits RNF125 to promote ubiquitination and degradation of RIGI (PubMed:26471729).
Biological Process
Biological Process ER-associated misfolded protein catabolic process Source:ParkinsonsUK-UCL1 Publication
Biological Process negative regulation of RIG-I signaling pathway Source:UniProtKB1 Publication
Biological Process negative regulation of type I interferon production Source:UniProtKB1 Publication
Biological Process retrograde protein transport, ER to cytosol Source:ParkinsonsUK-UCL1 Publication
Biological Process skeletal system development Source:ProtInc1 Publication
Biological Process ubiquitin-dependent ERAD pathway Source:ComplexPortal
Biological Process ubiquitin-dependent protein catabolic process Source:UniProtKB1 Publication
Cellular Location
Nucleus
Cytoplasm, cytosol
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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