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Mouse Anti-UFD1 Recombinant Antibody (CBT3760) (V2LY-0625-LY546)


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Tested Data
Mouse Anti-UFD1 Recombinant Antibody (CBT3760) (V2LY-0625-LY546) in ELISA
Mouse Anti-UFD1 Recombinant Antibody (CBT3760) (V2LY-0625-LY546) in ELISA
Mouse Anti-UFD1 Recombinant Antibody (CBT3760) (V2LY-0625-LY546) in WB
Mouse Anti-UFD1 Recombinant Antibody (CBT3760) (V2LY-0625-LY546) in WB
Mouse Anti-UFD1 Recombinant Antibody (CBT3760) (V2LY-0625-LY546) in WB
Mouse Anti-UFD1 Recombinant Antibody (CBT3760) (V2LY-0625-LY546) in WB
Mouse Anti-UFD1 Recombinant Antibody (CBT3760) (V2LY-0625-LY546) in IF
Mouse Anti-UFD1 Recombinant Antibody (CBT3760) (V2LY-0625-LY546) in IF
Mouse Anti-UFD1 Recombinant Antibody (CBT3760) (V2LY-0625-LY546) in IHC
Mouse Anti-UFD1 Recombinant Antibody (CBT3760) (V2LY-0625-LY546) in IHC
Mouse Anti-UFD1 Recombinant Antibody (CBT3760) (V2LY-0625-LY546) in IHC
Mouse Anti-UFD1 Recombinant Antibody (CBT3760) (V2LY-0625-LY546) in IHC

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT3760
Antibody Isotype
IgG1
Application
IHC, ICC

Basic Information

Immunogen
Purified recombinant fragment of human UFD1L (AA: 208-307) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
IHC-P1:200-1:1,000
ICC1:200-1:1,000
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Entrez Gene ID
7353
Function
Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures (By similarity).
Acts as a negative regulator of type I interferon production via the complex formed with VCP and NPLOC4, which binds to RIGI and recruits RNF125 to promote ubiquitination and degradation of RIGI (PubMed:26471729).
Biological Process
Biological Process ER-associated misfolded protein catabolic process Source:ParkinsonsUK-UCL1 Publication
Biological Process negative regulation of RIG-I signaling pathway Source:UniProtKB1 Publication
Biological Process negative regulation of type I interferon production Source:UniProtKB1 Publication
Biological Process retrograde protein transport, ER to cytosol Source:ParkinsonsUK-UCL1 Publication
Biological Process skeletal system development Source:ProtInc1 Publication
Biological Process ubiquitin-dependent ERAD pathway Source:ComplexPortal
Biological Process ubiquitin-dependent protein catabolic process Source:UniProtKB1 Publication
Cellular Location
Nucleus
Cytoplasm, cytosol
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For research use only. Not intended for any clinical use.

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