Mouse Anti-UFD1 Recombinant Antibody (CBT3760) (V2LY-0625-LY546)

Name: Mouse Anti-UFD1 Recombinant Antibody (CBT3760)
SKU: V2LY-0625-LY546
Rating: 5 (1 reviews)

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Tested Data

Mouse Anti-UFD1 Recombinant Antibody (CBT3760) (V2LY-0625-LY546) in ELISA

Mouse Anti-UFD1 Recombinant Antibody (CBT3760) (V2LY-0625-LY546) in WB

Mouse Anti-UFD1 Recombinant Antibody (CBT3760) (V2LY-0625-LY546) in IF

Mouse Anti-UFD1 Recombinant Antibody (CBT3760) (V2LY-0625-LY546) in IHC

Datasheet

SDS

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Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBT3760

Application

IHC, ICC

Immunogen

Purified recombinant fragment of human UFD1L (AA: 208-307) expressed in E. Coli.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:500-1:2,000
IHC-P	1:200-1:1,000
ICC	1:200-1:1,000
ELISA	1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

Sodium azide

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Ubiquitin Recognition Factor In ER Associated Degradation 1

Entrez Gene ID

7353

Function

Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures (By similarity).
Acts as a negative regulator of type I interferon production via the complex formed with VCP and NPLOC4, which binds to RIGI and recruits RNF125 to promote ubiquitination and degradation of RIGI (PubMed:26471729).

Biological Process

Biological Process ER-associated misfolded protein catabolic process Source:ParkinsonsUK-UCL1 Publication
Biological Process negative regulation of RIG-I signaling pathway Source:UniProtKB1 Publication
Biological Process negative regulation of type I interferon production Source:UniProtKB1 Publication
Biological Process retrograde protein transport, ER to cytosol Source:ParkinsonsUK-UCL1 Publication
Biological Process skeletal system development Source:ProtInc1 Publication
Biological Process ubiquitin-dependent ERAD pathway Source:ComplexPortal
Biological Process ubiquitin-dependent protein catabolic process Source:UniProtKB1 Publication

Cellular Location

Nucleus
Cytoplasm, cytosol

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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