UFD1

The protein encoded by this gene forms a complex with two other proteins, nuclear protein localization-4 and valosin-containing protein, and this complex is necessary for the degradation of ubiquitinated proteins. In addition, this complex controls the disassembly of the mitotic spindle and the formation of a closed nuclear envelope after mitosis. Mutations in this gene have been associated with Catch 22 syndrome as well as cardiac and craniofacial defects. Alternative splicing results in multiple transcript variants encoding different isoforms. A related pseudogene has been identified on chromosome 18. [provided by RefSeq, Jun 2009]
Full Name
Ubiquitin Recognition Factor In ER Associated Degradation 1
Function
Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures (By similarity).
Acts as a negative regulator of type I interferon production via the complex formed with VCP and NPLOC4, which binds to RIGI and recruits RNF125 to promote ubiquitination and degradation of RIGI (PubMed:26471729).
Biological Process
Biological Process ER-associated misfolded protein catabolic process Source:ParkinsonsUK-UCL1 Publication
Biological Process negative regulation of RIG-I signaling pathway Source:UniProtKB1 Publication
Biological Process negative regulation of type I interferon production Source:UniProtKB1 Publication
Biological Process retrograde protein transport, ER to cytosol Source:ParkinsonsUK-UCL1 Publication
Biological Process skeletal system development Source:ProtInc1 Publication
Biological Process ubiquitin-dependent ERAD pathway Source:ComplexPortal
Biological Process ubiquitin-dependent protein catabolic process Source:UniProtKB1 Publication
Cellular Location
Nucleus
Cytoplasm, cytosol
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Anti-UFD1 antibodies

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Mouse Anti-UFD1 Recombinant Antibody (8G6) (CBMAB-C4525-CN)

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Target: UFD1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 8G6
Application*: WB, IH
Datasheet SDS

Mouse Anti-UFD1 Recombinant Antibody (7C9) (CBMAB-C4524-CN)

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Target: UFD1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 7C9
Application*: P, WB
Datasheet SDS

Mouse Anti-UFD1 Recombinant Antibody (5E3) (CBMAB-C4523-CN)

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Target: UFD1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5E3
Application*: WB
Datasheet SDS

Mouse Anti-UFD1 Recombinant Antibody (4F11A4) (CBMAB-C4522-CN)

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Target: UFD1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4F11A4
Application*: E, WB, P, IF
Datasheet SDS

Mouse Anti-UFD1 Recombinant Antibody (4C7) (CBMAB-C4521-CN)

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Target: UFD1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4C7
Application*: P, WB
Datasheet SDS

Mouse Anti-UFD1 Recombinant Antibody (3F1) (CBMAB-C4520-CN)

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Target: UFD1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3F1
Application*: WB
Datasheet SDS

Mouse Anti-UFD1 Recombinant Antibody (3E9) (CBMAB-C4519-CN)

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Target: UFD1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3E9
Application*: WB
Datasheet SDS

Mouse Anti-UFD1 Recombinant Antibody (3B4) (CBMAB-C4518-CN)

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Target: UFD1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3B4
Application*: WB
Datasheet SDS

Mouse Anti-UFD1 Recombinant Antibody (3A12) (CBMAB-C4517-CN)

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Target: UFD1
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: 3A12
Application*: WB
Datasheet SDS

Mouse Anti-UFD1 Recombinant Antibody (2A6F3) (CBMAB-C4516-CN)

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Target: UFD1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 2A6F3
Application*: E, WB, P, IF, FC
Datasheet SDS

Mouse Anti-UFD1 Recombinant Antibody (19/Ufd1L) (CBMAB-C4515-CN)

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Target: UFD1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Human, Rat
Clone: 19/Ufd1L
Application*: WB, IF
Datasheet SDS

Recombinant Mouse Anti-Ufd1 Recombinant Antibody (5E2) (CBMAB-XB1200-YC)

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Target: UFD1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Mouse, Human, Rat, Frog
Clone: 5E2
Application*: E, IF, IP, WB
Datasheet SDS

Mouse Anti-UFD1 Recombinant Antibody (CBT3760) (V2LY-0625-LY546)

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Target: UFD1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3760
Application*: IH, IC
Datasheet SDS

Mouse Anti-UFD1 Recombinant Antibody (CBT2841) (V2LY-0625-LY545)

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Target: UFD1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBT2841
Application*: WB, IH, IC, F
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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