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Rabbit Anti-USP14 Recombinant Antibody (CBXU-158) (CBMAB-U0227-CQ)

This product is a rabbit antibody that recognizes USP14. The antibody CBXU-158 can be used for immunoassay techniques such as: WB, IP.
See all USP14 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat, Hamster, Cattle, Dog
Clone
CBXU-158
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Specificity
Human, Mouse, Rat, Hamster, Cattle, Dog
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Ubiquitin Specific Peptidase 14
Introduction
This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. Among its related pathways are Deubiquitination and Ubiquitin-Proteasome Dependent Proteolysis.
Entrez Gene ID
Human9097
Mouse59025
Rat291796
Cattle505106
Dog480182
Hamster101842728
UniProt ID
HumanP54578
MouseQ9JMA1
RatF7EK08
CattleQ0IIF7
DogA0A8I3MZA5
HamsterA0A1U8CR18
Alternative Names
TGT; ubiquitin specific peptidase 14
Function
Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome (PubMed:18162577, PubMed:28396413).
Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell (PubMed:18162577).
Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (PubMed:19106094).
Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1 (PubMed:19135427).
Indispensable for synaptic development and function at neuromuscular junctions (NMJs) (By similarity).
Plays a role in the innate immune defense against viruses by stabilizing the viral DNA sensor CGAS and thus inhibiting its autophagic degradation (PubMed:27666593).
Biological Process
Biological Process chemical synaptic transmission Source:Ensembl
Biological Process innate immune response Source:UniProtKB-KW
Biological Process negative regulation of ER-associated ubiquitin-dependent protein catabolic process Source:ParkinsonsUK-UCL1 Publication
Biological Process positive regulation of NF-kappaB transcription factor activity Source:Reactome
Biological Process proteasome-mediated ubiquitin-dependent protein catabolic process Source:InterPro
Biological Process protein deubiquitination Source:FlyBase1 Publication
Biological Process regulation of chemotaxis Source:UniProtKB1 Publication
Biological Process regulation of proteasomal protein catabolic process Source:UniProtKB1 Publication
Cellular Location
Cytoplasm
Cell membrane
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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