Human Recombinant USP14 protein, His Tag (V2LY-0526-LY7560)

Name: Human Recombinant USP14 protein, His Tag
SKU: V2LY-0526-LY7560
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

E. coli

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant USP14 protein, His Tag consist of Amino Acid: 1-494 and predicts a molecular mass of 56.9 kDa.

Molecule Mass

56.9 kDa

Sequence

Amino Acid: 1-494

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

≥95% as determined by SDS-PAGE.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Ubiquitin Specific Peptidase 14

Function

Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome (PubMed:18162577, PubMed:28396413).
Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell (PubMed:18162577).
Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (PubMed:19106094).
Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1 (PubMed:19135427).
Indispensable for synaptic development and function at neuromuscular junctions (NMJs) (By similarity).
Plays a role in the innate immune defense against viruses by stabilizing the viral DNA sensor CGAS and thus inhibiting its autophagic degradation (PubMed:27666593).

Biological Process

Biological Process chemical synaptic transmission Source:Ensembl
Biological Process innate immune response Source:UniProtKB-KW
Biological Process negative regulation of ER-associated ubiquitin-dependent protein catabolic process Source:ParkinsonsUK-UCL1 Publication
Biological Process positive regulation of NF-kappaB transcription factor activity Source:Reactome
Biological Process proteasome-mediated ubiquitin-dependent protein catabolic process Source:InterPro
Biological Process protein deubiquitination Source:FlyBase1 Publication
Biological Process regulation of chemotaxis Source:UniProtKB1 Publication
Biological Process regulation of proteasomal protein catabolic process Source:UniProtKB1 Publication

Cellular Location

Cytoplasm
Cell membrane

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant USP14 protein, GST Tag (CAT#: V2LY-0526-LY7559)

USP14 Matched Antibody Pair (1296) (CAT#: APMAB-1296LY)

Antibody Pairs

USP14 Matched Antibody Pair (1296) (CAT#: APMAB-1296LY)

Related Products

Rabbit Anti-USP14 Recombinant Antibody (CBXU-025) (CAT#: CBMAB-U0141-CQ)

Rabbit Anti-USP14 Recombinant Antibody (CBXU-158) (CAT#: CBMAB-U0227-CQ)

Mouse Anti-USP14 Antibody (9H6) (CAT#: CBMAB-1770CQ)

Mouse Anti-USP14 (aa 395-494) Recombinant Antibody (6D6) (CAT#: CBMAB-U0105-CQ)

Mouse Anti-USP14 Antibody (5G6) (CAT#: CBMAB-1769CQ)

USP14 Matched Antibody Pair (1296) (CAT#: APMAB-1296LY)

Rabbit Anti-USP14 Recombinant Antibody (
28C4) (CAT#: V2LY-0725-LY1283)

Human Recombinant USP14 protein, GST Tag (CAT#: V2LY-0526-LY7559)

Mouse Anti-USP14 (aa 395-494) Recombinant Antibody (1F8) (CAT#: CBMAB-U0033-CQ)

Mouse Anti-USP14 Recombinant Antibody (889CT6.2.1) (CAT#: CBMAB-U0110-CQ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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