Human Recombinant USP14 protein, GST Tag (V2LY-0526-LY7559)
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Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell (PubMed:18162577).
Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (PubMed:19106094).
Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1 (PubMed:19135427).
Indispensable for synaptic development and function at neuromuscular junctions (NMJs) (By similarity).
Plays a role in the innate immune defense against viruses by stabilizing the viral DNA sensor CGAS and thus inhibiting its autophagic degradation (PubMed:27666593).
Biological Process innate immune response Source:UniProtKB-KW
Biological Process negative regulation of ER-associated ubiquitin-dependent protein catabolic process Source:ParkinsonsUK-UCL1 Publication
Biological Process positive regulation of NF-kappaB transcription factor activity Source:Reactome
Biological Process proteasome-mediated ubiquitin-dependent protein catabolic process Source:InterPro
Biological Process protein deubiquitination Source:FlyBase1 Publication
Biological Process regulation of chemotaxis Source:UniProtKB1 Publication
Biological Process regulation of proteasomal protein catabolic process Source:UniProtKB1 Publication
Cell membrane
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols
Alternative Versions
Human Recombinant USP14 protein, His Tag (CAT#: V2LY-0526-LY7560)
Antibody Pairs
USP14 Matched Antibody Pair (1296) (CAT#: APMAB-1296LY)
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USP14 Matched Antibody Pair (1296) (CAT#: APMAB-1296LY)
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Human Recombinant USP14 protein, His Tag (CAT#: V2LY-0526-LY7560)
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Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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