Rat Anti-WNT8B Recombinant Antibody (CBWJW-073) (CBMAB-W0227-WJ)

Name: Rat Anti-WNT8B Recombinant Antibody (CBWJW-073)
SKU: CBMAB-W0227-WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rat

Clone

CBWJW-073

Application

ELISA, IHC-P, WB

Immunogen

E. coli-derived rmWnt-8b

Specificity

Mouse

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Concentration

0.5 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Wnt Family Member 8B

Introduction

WNT8B shows 95%, 86% and 71% amino acid identity to the mouse, zebrafish and Xenopus Wnt8B proteins, respectively. The expression patterns of the human and mouse genes appear identical and are restricted to the developing brain. The chromosomal location of this gene to 10q24 suggests it as a candidate gene for partial epilepsy.

Entrez Gene ID

22423

UniProt ID

Q9WUD6

Alternative Names

WNT8B; Wnt family member 8B

Function

Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus.

Biological Process

Biological Process canonical Wnt signaling pathway Source:WormBase1 Publication
Biological Process cell fate commitment Source:GO_Central1 Publication
Biological Process cellular response to retinoic acid Source:UniProtKB
Biological Process determination of dorsal identity Source:BHF-UCLBy Similarity
Biological Process gastrulation Source:BHF-UCLBy Similarity
Biological Process nervous system development Source:ProtInc1 Publication
Biological Process neuron differentiation Source:UniProtKB
Biological Process response to estradiol Source:BHF-UCL1 Publication
Biological Process response to retinoic acid Source:BHF-UCL1 Publication
Biological Process signal transduction Source:ProtInc1 Publication

Cellular Location

Secreted, extracellular space, extracellular matrix

PTM

Palmitoleoylation is required for efficient binding to frizzled receptors (By similarity).
Depalmitoleoylation leads to Wnt signaling pathway inhibition (By similarity).
Proteolytic processing by TIKI1 and TIKI2 promotes oxidation and formation of large disulfide-bond oligomers, leading to inactivation of WNT8B.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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