WNT8B

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 95%, 86% and 71% amino acid identity to the mouse, zebrafish and Xenopus Wnt8B proteins, respectively. The expression patterns of the human and mouse genes appear identical and are restricted to the developing brain. The chromosomal location of this gene to 10q24 suggests it as a candidate gene for partial epilepsy.
Full Name
Wnt Family Member 8B
Function
Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus.
Biological Process
Biological Process canonical Wnt signaling pathway Source:WormBase1 Publication
Biological Process cell fate commitment Source:GO_Central1 Publication
Biological Process cellular response to retinoic acid Source:UniProtKB
Biological Process determination of dorsal identity Source:BHF-UCLBy Similarity
Biological Process gastrulation Source:BHF-UCLBy Similarity
Biological Process nervous system development Source:ProtInc1 Publication
Biological Process neuron differentiation Source:UniProtKB
Biological Process response to estradiol Source:BHF-UCL1 Publication
Biological Process response to retinoic acid Source:BHF-UCL1 Publication
Biological Process signal transduction Source:ProtInc1 Publication
Cellular Location
Secreted, extracellular space, extracellular matrix
PTM
Palmitoleoylation is required for efficient binding to frizzled receptors (By similarity).
Depalmitoleoylation leads to Wnt signaling pathway inhibition (By similarity).
Proteolytic processing by TIKI1 and TIKI2 promotes oxidation and formation of large disulfide-bond oligomers, leading to inactivation of WNT8B.
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Anti-WNT8B antibodies

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Rat Anti-WNT8B Recombinant Antibody (CBWJW-115) (CBMAB-W0264-WJ)

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Target: WNT8B
Host: Rat
Specificity: Mouse
Clone: CBWJW-115
Application*: IH
Datasheet SDS

Rat Anti-WNT8B Recombinant Antibody (CBWJW-074) (CBMAB-W0228-WJ)

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Target: WNT8B
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBWJW-074
Application*: E, P
Datasheet SDS

Rat Anti-WNT8B Recombinant Antibody (CBWJW-073) (CBMAB-W0227-WJ)

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Target: WNT8B
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBWJW-073
Application*: E, P, WB
Datasheet SDS

Rat Anti-WNT8B Recombinant Antibody (CBWJW-072) (CBMAB-W0226-WJ)

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Target: WNT8B
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBWJW-072
Application*: E, WB
Datasheet SDS

Rat Anti-WNT8B Recombinant Antibody (7H99) (CBMAB-W0152-WJ)

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Target: WNT8B
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: 7H99
Application*: E, WB
Datasheet SDS

Rat Anti-WNT8B Recombinant Antibody (7H100) (CBMAB-W0149-WJ)

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Target: WNT8B
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: 7H100
Application*: E, IH
Datasheet SDS

Rat Anti-WNT8B Recombinant Antibody (CBWJW-195) (CBMAB-W0082-WJ)

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Target: WNT8B
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: CBWJW-195
Application*: IH
Datasheet SDS

Rat Anti-WNT8B Recombinant Antibody (CBWJW-194) (CBMAB-W0081-WJ)

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Target: WNT8B
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBWJW-194
Application*: WB
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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