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Rat Anti-WNT8B Recombinant Antibody (CBWJW-194) (CBMAB-W0081-WJ)

This product is a rat antibody that recognizes WNT8B . The antibody CBWJW-194 can be used for immunoassay techniques such as: WB.
See all WNT8B antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBWJW-194
Antibody Isotype
IgG2a
Application
WB

Basic Information

Immunogen
E. coli-derived recombinant Mouse Wnt-8b, Trp22-Glu52, Leu195-Arg269.
Specificity
Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Wnt Family Member 8B
Introduction
WNT8B shows 95%, 86% and 71% amino acid identity to the mouse, zebrafish and Xenopus Wnt8B proteins, respectively. The expression patterns of the human and mouse genes appear identical and are restricted to the developing brain. The chromosomal location of this gene to 10q24 suggests it as a candidate gene for partial epilepsy.
Entrez Gene ID
22423
UniProt ID
Q9WUD6
Alternative Names
WNT8B; Wnt family member 8B
Function
Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus.
Biological Process
Biological Process canonical Wnt signaling pathway Source:WormBase1 Publication
Biological Process cell fate commitment Source:GO_Central1 Publication
Biological Process cellular response to retinoic acid Source:UniProtKB
Biological Process determination of dorsal identity Source:BHF-UCLBy Similarity
Biological Process gastrulation Source:BHF-UCLBy Similarity
Biological Process nervous system development Source:ProtInc1 Publication
Biological Process neuron differentiation Source:UniProtKB
Biological Process response to estradiol Source:BHF-UCL1 Publication
Biological Process response to retinoic acid Source:BHF-UCL1 Publication
Biological Process signal transduction Source:ProtInc1 Publication
Cellular Location
Secreted, extracellular space, extracellular matrix
PTM
Palmitoleoylation is required for efficient binding to frizzled receptors (By similarity).
Depalmitoleoylation leads to Wnt signaling pathway inhibition (By similarity).
Proteolytic processing by TIKI1 and TIKI2 promotes oxidation and formation of large disulfide-bond oligomers, leading to inactivation of WNT8B.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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