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ARHGEF1 Matched Antibody Pair (104) (APMAB-104LY)


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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Mouse anti-ARHGEF1 monoclonal antibody, 100 ug
Detection Antibody
Anti-ARHGEF1 Rabbit polyclonal antibody, 50 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008]
Alternative Names
Rho Guanine Nucleotide Exchange Factor 1; Rho Guanine Nucleotide Exchange Factor (GEF) 1; 115 KDa Guanine Nucleotide Exchange Factor; P115-RHOGEF; P115RhoGEF; SUB1.5;
Entrez Gene ID
9138
UniProt ID
Q92888
More Infomation

Gheyouche, E., Bagueneau, M., Loirand, G., Offmann, B., & Téletchéa, S. (2021). Structural Design and Analysis of the RHOA-ARHGEF1 Binding Mode: Challenges and Applications for Protein-Protein Interface Prediction. Frontiers in molecular biosciences, 8, 333.

Bouafia, A., Lofek, S., Bruneau, J., Chentout, L., Lamrini, H., Trinquand, A., ... & Kracker, S. (2019). Loss of ARHGEF1 causes a human primary antibody deficiency. The Journal of clinical investigation, 129(3), 1047-1060.

Shaifta, Y., MacKay, C. E., Irechukwu, N., O'Brien, K. A., Wright, D. B., Ward, J. P., & Knock, G. A. (2018). Transforming growth factor‐β enhances Rho‐kinase activity and contraction in airway smooth muscle via the nucleotide exchange factor ARHGEF1. The Journal of physiology, 596(1), 47-66.

MacKay, C. E., Shaifta, Y., Snetkov, V. V., Francois, A. A., Ward, J. P., & Knock, G. A. (2017). ROS-dependent activation of RhoA/Rho-kinase in pulmonary artery: role of Src-family kinases and ARHGEF1. Free Radical Biology and Medicine, 110, 316-331.

Toffali, L., Montresor, A., Mirenda, M., Scita, G., & Laudanna, C. (2017). SOS1, ARHGEF1, and DOCK2 rho-GEFs mediate JAK-dependent LFA-1 activation by chemokines. The Journal of Immunology, 198(2), 708-717.

Carbone, M. L., Chadeuf, G., Heurtebise-Chrétien, S., Prieur, X., Quillard, T., Goueffic, Y., ... & Loirand, G. (2017). Leukocyte RhoA exchange factor Arhgef1 mediates vascular inflammation and atherosclerosis. The Journal of clinical investigation, 127(12), 4516-4526.

Xiang, X., Zhuang, X., Li, S., & Shi, L. (2017). Arhgef1 is expressed in cortical neural progenitor cells and regulates neurite outgrowth of newly differentiated neurons. Neuroscience letters, 638, 27-34.

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For research use only. Not intended for any clinical use.

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