BCAR1 Matched Antibody Pair (132) (APMAB-132LY)

This antibody pair set can be used for detecting and quantifying protein level of human BCAR1.
See all BCAR1 antibodies

Datasheet

Specifications

ApplIcation

Sandwich ELISA

Specificity

Human

Capture Antibody

Rabbit anti-BCAR1 polyclonal antibody, 100 ug

Detection Antibody

Anti-BCAR1 Mouse polyclonal antibody, 20 ug

Dilutions

10 ng/ml-100 ng/ml

Format

Liquid

Storage

Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.

Introduction

The protein encoded by this gene is a member of the Crk-associated substrate (CAS) family of scaffold proteins, characterized by the presence of multiple protein-protein interaction domains and many serine and tyrosine phosphorylation sites. The encoded protein contains a Src-homology 3 (SH3) domain, a proline-rich domain, a substrate domain which contains 15 repeat of the YxxP consensus phosphorylation motif for Src family kinases, a serine-rich domain, and a bipartite Src-binding domain, which can bind both SH2 and SH3 domains. This adaptor protein functions in multiple cellular pathways, including in cell motility, apoptosis and cell cycle control. Dysregulation of this gene can have a wide range of effects, affecting different pathways, including cardiac development, vascular smooth muscle cells, liver and kidney function, endothelial migration, and cancer. [provided by RefSeq, Sep 2017]

Alternative Names

BCAR1, Cas Family Scaffolding Protein; Cas Scaffolding Protein Family Member 1; Crk-Associated Substrate; P130Cas; CASS1; CRKAS;

Entrez Gene ID

9564

UniProt ID

P56945

References

Bauer, J., Gombocz, E., Schulz, H., Hauslage, J., & Grimm, D. (2021). Interaction Network Provides Clues on the Role of Bcar1 in Cellular Response to Changes in Gravity. Computation, 9(8), 81.

Guo, A. K., Itahana, Y., Seshachalam, V. P., Chow, H. Y., Ghosh, S., & Itahana, K. (2021). Mutant TP53 interacts with BCAR1 to contribute to cancer cell invasion. British Journal of Cancer, 124(1), 299-312.

Wisniewski, L., French, V., Lockwood, N., Valdivia, L. E., & Frankel, P. (2020). P130Cas/bcar1 mediates zebrafish caudal vein plexus angiogenesis. Scientific reports, 10(1), 1-14.

Kuikui, Z., Yangchao, Z., Lu, W., Sijia, Z., Yan, Z., Zhenyu, L., ... & Meng, R. (2020). Novel Germline Mutation in BCAR1 in Two Siblings With Lung Cancer: a Possible Susceptibility Gene.

Jiang, S., Mao, C., Jiang, B., Tan, Q., & Deng, B. (2020). High Expression of BCAR1 by Circulating Tumor Cells and Tumor Tissues Is Predictive of a Poor Prognosis of Early-Stage Lung Adenocarcinoma Potentially Due to Regulation of Epithelial-Mesenchymal Transition. Technology in cancer research & treatment, 19, 1533033820983086.

Li, Y., Luo, K., Yin, Y., Wu, C., Deng, M., Li, L., ... & Yuan, J. (2017). USP13 regulates the RAP80-BRCA1 complex dependent DNA damage response. Nature communications, 8(1), 1-12.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Related Products

Mouse Anti-BCAR1 Recombinant Antibody (CBYY-0274)

Mouse Anti-BCAR1 Recombinant Antibody (CBYY-0286)

Mouse Anti-BCAR1 Recombinant Antibody (C-2)

Mouse Anti-BCAR1 Recombinant Antibody (1B1)

Mouse Anti-BCAR1 Recombinant Antibody (CBYY-0276)

Rabbit Anti-BCAR1 Recombinant Antibody (EG362)

Rabbit Anti-BCAR1 Recombinant Antibody (E1L9H)

Mouse Anti-BCAR1 Recombinant Antibody (CBYY-0279)

Mouse Anti-BCAR1 Recombinant Antibody (1H9)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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