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DGKZ Matched Antibody Pair (339) (APMAB-339LY)


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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-DGKZ polyclonal antibody, 100 ug
Detection Antibody
Anti-DGKZ Mouse polyclonal antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It may attenuate protein kinase C activity by regulating diacylglycerol levels in intracellular signaling cascade and signal transduction. Alternative splicing occurs at this locus and multiple transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Nov 2010]
Alternative Names
Diacylglycerol Kinase Zeta; Diacylglycerol Kinase, Zeta 104kDa; Diglyceride Kinase Zeta; DAG Kinase Zeta; EC 2.7.1.107; DGK-ZETA; DAGK6; HDGKzeta; DAGK5;
Entrez Gene ID
8525
UniProt ID
Q13574
More Infomation

Zhao, Y., Sun, H., Li, X., Liu, Q., Liu, Y., Hou, Y., & Jin, W. (2022). DGKZ promotes TGFβ signaling pathway and metastasis in triple-negative breast cancer by suppressing lipid raft-dependent endocytosis of TGFβR2. Cell death & disease, 13(2), 1-12.

Liu, K., Xue, B., Bai, G., & Zhang, W. (2021). Downregulation of Diacylglycerol kinase zeta (DGKZ) suppresses tumorigenesis and progression of cervical cancer by facilitating cell apoptosis and cell cycle arrest. Bioengineered, 12(1), 1517-1529.

Li, H., Dong, C., Tian, Y., Li, X., Wang, B., Zhai, D., ... & Chao, X. (2019). Knockdown of diacylglycerol kinase zeta (DGKZ) induces apoptosis and G2/M phase arrest in human acute myeloid leukemia HL-60 cells through MAPK/survivin/caspase pathway. Die Pharmazie-An International Journal of Pharmaceutical Sciences, 74(7), 418-422.

Yu, W., Tang, L., Lin, F., Yao, Y., & Shen, Z. (2019). DGKZ acts as a potential oncogene in osteosarcoma proliferation through its possible interaction with ERK1/2 and MYC pathway. Frontiers in Oncology, 8, 655.

Alinaghi, S., Alehabib, E., Johari, A. H., Vafaei, F., Salehi, S., Darvish, H., & Ghaedi, H. (2019). Expression analysis and genotyping of dgkz: a gwas-derived risk gene for schizophrenia. Molecular biology reports, 46(4), 4105-4111.

Jing, W., Gershan, J. A., Holzhauer, S., Weber, J., Palen, K., McOlash, L., ... & Riese, M. J. (2017). T cells deficient in diacylglycerol kinase ζ are resistant to PD-1 inhibition and help create persistent host immunity to leukemia. Cancer Research, 77(20), 5676-5686.

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For research use only. Not intended for any clinical use.

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